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Ribes nigrum L. Extract-Mediated Green Synthesis and Antibacterial Action Mechanisms of Silver Nanoparticles
Abstract
Silver nanoparticles (Ag NPs) represent one of the most widely employed metal-based engineered nanomaterials with a broad range of applications in different areas of science. Plant extracts (PEs) serve as green reducing and coating agents and can be exploited for the generation of Ag NPs. In this study, the phytochemical composition of ethanolic extract of black currant (Ribes nigrum) leaves was determined. The main components of extract include quercetin rutinoside, quercetin hexoside, quercetin glucuronide, quercetin malonylglucoside and quercitrin. The extract was subsequently employed for the green synthesis of Ag NPs. Consequently, R. nigrum leaf extract and Ag NPs were evaluated for potential antibacterial activities against Gram-negative bacteria (Escherichia coli ATCC 25922 and kanamycin-resistant E. coli pARG-25 strains). Intriguingly, the plant extract did not show any antibacterial effect, whilst Ag NPs demonstrated significant activity against tested bacteria. Biogenic Ag NPs affect the ATPase activity and energy-dependent H+-fluxes in both strains of E. coli, even in the presence of N,N’-dicyclohexylcarbodiimide (DCCD). Thus, the antibacterial activity of the investigated Ag NPs can be explained by their impact on the membrane-associated properties of bacteria.
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Authors (12)
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Zaruhi Hovhannisyan
- Saarland University
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Marina Timotina
- Russian-Armenian University
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Jemma Manoyan
- Yerevan State University
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Lilit Gabrielyan
- Yerevan State University
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Margarit Petrosyan
- Yerevan State University
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Mikayel Ginovyan PhD
- Yerevan State University
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Karen Trchounian
- Yerevan State University,
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Naira Sahakyan
- Yerevan State University,
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Muhammad Jawad Nasim
- Saarland University
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Full text
- Publication version
- Accepted or Published Version
- DOI:
- Digital Object Identifier (open in new tab) 10.3390/antibiotics11101415
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Details
- Category:
- Articles
- Type:
- artykuły w czasopismach
- Published in:
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Antibiotics-Basel
no. 11,
ISSN: 2079-6382 - Language:
- English
- Publication year:
- 2022
- Bibliographic description:
- Hovhannisyan Z., Timotina M., Manoyan J., Gabrielyan L., Petrosyan M., Kusznierewicz B., Bartoszek-Pączkowska A., Jacob C., Ginovyan M., Trchounian K., Sahakyan N., Nasim M. J.: Ribes nigrum L. Extract-Mediated Green Synthesis and Antibacterial Action Mechanisms of Silver Nanoparticles// Antibiotics-Basel -Vol. 11,iss. 10 (2022), s.1415-
- DOI:
- Digital Object Identifier (open in new tab) 10.3390/antibiotics11101415
- Verified by:
- Gdańsk University of Technology
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