Studies on the influence of β-cyclodextrin derivatives on the physical stability of famotidine

Marzena Jamrógiewicz; Karolina Milewska

doi:https://doi.org/10.1016/j.saa.2019.04.066

Studies on the influence of β-cyclodextrin derivatives on the physical stability of famotidine

Abstract

The usage of Fourier transform infrared spectroscopy, near infrared spectroscopy, differential scanning calorimetry and microscopy is presented in this work focused on the exploration of the effect of CD on the physical stability of famotidine (FAM). The most significant information was achieved by analysis of the second derivatives of
near infrared (NIR) spectra recorded. Changes in the shape of spectra derivatives allow to observe the improvement of physical stability of FAM with the usage of various supramolecular systems based on β-cyclodextrin (CD) derivatives. The comparison was performed with the usage of maltodextrin in FAM mixtures. We found out that
β-cyclodextrin derivatives in the form of physical mixture and inclusion complexes successfully increased the physical stability of famotidine in solid state while maltodextrin does not show positive effect in imparting physical stability to famotidine