Synthesis, anticandidal activity of N3-(4-methoxyfumaroyl)-(S)-2,3-diaminopropanoic amide derivatives – Novel inhibitors of glucosamine-6-phosphate synthase - Publication - Bridge of Knowledge

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Synthesis, anticandidal activity of N3-(4-methoxyfumaroyl)-(S)-2,3-diaminopropanoic amide derivatives – Novel inhibitors of glucosamine-6-phosphate synthase

Abstract

Novel FMDP amiders 4-6 have been synthesized and tested against Candida strains. The anticandidal activity has been confined only to Candida albicans. Anticandidal activity of the tested amides has correlated with their inhibitory activity of glucosamine-6-phosphate synthase in cell free extract from Candida albicans.

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Category:
Articles
Type:
artykuł w czasopiśmie wyróżnionym w JCR
Published in:
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY no. 90, pages 577 - 582,
ISSN: 0223-5234
Language:
English
Publication year:
2015
Bibliographic description:
Pawlak D., Stolarska M., Wojciechowski M., Andruszkiewicz R.: Synthesis, anticandidal activity of N3-(4-methoxyfumaroyl)-(S)-2,3-diaminopropanoic amide derivatives – Novel inhibitors of glucosamine-6-phosphate synthase// EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY. -Vol. 90, (2015), s.577-582
DOI:
Digital Object Identifier (open in new tab) 10.1016/j.ejmech.2014.12.007
Verified by:
Gdańsk University of Technology

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