Synthesis, Antimicrobial and Mutagenic Activity of a New Class of d-Xylopyranosides - Publication - Bridge of Knowledge

Your account

login

Search

Synthesis, Antimicrobial and Mutagenic Activity of a New Class of d-Xylopyranosides

Abstract

Eight N-[2-(2′,3′,4′-tri-O-acetyl-α/β-d-xylopyranosyloxy)ethyl]ammonium bromides, a new class of d-xylopyranosides containing a quaternary ammonium aglycone, were obtained. Their complete structure was confirmed using NMR spectroscopy (1H, 13C, COSY and HSQC) and high-resolution mass spectrometry (HRMS). An antimicrobial activity against fungi (Candida albicans, Candida glabrata) and bacteria (Staphylococcus aureus, Escherichia coli) and a mutagenic Ames test with Salmonella typhimurium TA 98 strain were performed for the obtained compounds. The greatest activity against the tested microorganisms was shown by glycosides with the longest (octyl) hydrocarbon chain in ammonium salt. None of the tested compounds exhibited mutagenic activity in the Ames test.

Citations

  • 1

    CrossRef

  • 0

    Web of Science

  • 1

    Scopus

Authors (8)

Cite as

Full text

download paper
downloaded 35 times
Publication version
Accepted or Published Version
DOI:
Digital Object Identifier (open in new tab) 10.3390/antibiotics12050888
License
Creative Commons: CC-BY open in new tab

Keywords

Details

Category:
Articles
Type:
artykuły w czasopismach
Published in:
Antibiotics-Basel no. 12,
ISSN: 2079-6382
Language:
English
Publication year:
2023
Bibliographic description:
Sikora K., Szweda P., Słoczyńska K., Samaszko-Fiertek J., Madaj J., Liberek B., Pękala E., Dmochowska B.: Synthesis, Antimicrobial and Mutagenic Activity of a New Class of d-Xylopyranosides// Antibiotics-Basel -,iss. 5 (2023), s.888-888
DOI:
Digital Object Identifier (open in new tab) 10.3390/antibiotics12050888
Sources of funding:
  • This study was supported by University of Gdansk, task grant no. DS/531-T100-D501-23.
Verified by:
Gdańsk University of Technology

seen 94 times

Recommended for you

Antimicrobial, Cytotoxic and Mutagenic Activity of Gemini QAS Derivatives of 1,4:3,6-Dianhydro-l-iditol

  • K. Sikora,
  • A. Nowacki,
  • P. Szweda
  • + 4 authors
2022

Oxolane Ammonium Salts (Muscarine-Like)—Synthesis and Microbiological Activity

  • P. Bogdanowicz,
  • J. Madaj,
  • P. Szweda
  • + 3 authors
2024

Efficient synthesis and antifungal investigation of nucleosides’ quaternary ammonium salt derivatives

  • B. Dmochowska,
  • L. Pellowska-Januszek,
  • J. Samaszko
  • + 3 authors
2019

Paenibacillus alvei MP1 as a Producer of the Proteinaceous Compound with Activity against Important Human Pathogens, Including Staphylococcus aureus and Listeria monocytogenes

  • M. Pajor,
  • Z. R. Xiong,
  • R. Worobo
  • + 1 authors
2020
Meta Tags