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Synthesis, Antimicrobial and Mutagenic Activity of a New Class of d-Xylopyranosides

Abstract

Eight N-[2-(2′,3′,4′-tri-O-acetyl-α/β-d-xylopyranosyloxy)ethyl]ammonium bromides, a new class of d-xylopyranosides containing a quaternary ammonium aglycone, were obtained. Their complete structure was confirmed using NMR spectroscopy (1H, 13C, COSY and HSQC) and high-resolution mass spectrometry (HRMS). An antimicrobial activity against fungi (Candida albicans, Candida glabrata) and bacteria (Staphylococcus aureus, Escherichia coli) and a mutagenic Ames test with Salmonella typhimurium TA 98 strain were performed for the obtained compounds. The greatest activity against the tested microorganisms was shown by glycosides with the longest (octyl) hydrocarbon chain in ammonium salt. None of the tested compounds exhibited mutagenic activity in the Ames test.

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DOI:
Digital Object Identifier (open in new tab) 10.3390/antibiotics12050888
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Category:
Articles
Type:
artykuły w czasopismach
Published in:
Antibiotics-Basel no. 12,
ISSN: 2079-6382
Language:
English
Publication year:
2023
Bibliographic description:
Sikora K., Szweda P., Słoczyńska K., Samaszko-Fiertek J., Madaj J., Liberek B., Pękala E., Dmochowska B.: Synthesis, Antimicrobial and Mutagenic Activity of a New Class of d-Xylopyranosides// Antibiotics-Basel -,iss. 5 (2023), s.888-888
DOI:
Digital Object Identifier (open in new tab) 10.3390/antibiotics12050888
Sources of funding:
  • This study was supported by University of Gdansk, task grant no. DS/531-T100-D501-23.
Verified by:
Gdańsk University of Technology

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