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Synthesis of 3-(2-Alkylthio-4-chloro-5-methylbenzenesulfonyl)-2-(1-phenyl-3-arylprop-2-enylideneamino)guanidine Derivatives with Pro-Apoptotic Activity against Cancer Cells
Abstract
The untypical course of reaction between chalcones and benzenesulfonylaminoguanidines led to the new 3-(2-alkylthio-4-chloro-5-methylbenzenesulfonyl)-2-(1-phenyl-3-arylprop-2- enylideneamino)guanidine derivatives 8–33. The new compounds were tested in vitro for their impact on the growth of breast cancer cells MCF-7, cervical cancer cells HeLa and colon cancer cells HCT-116 by MTT assay. The results revealed that the activity of derivatives is strongly related to the presence of hydroxy group in the benzene ring at the 3-arylpropylidene fragment. The most cytotoxic compounds 20 and 24 displayed mean IC50 values of 12.8 and 12.7 uM, respectively, against three tested cell lines and were almost 3- and 4-fold more active toward MCF-7 and HCT-116 when compared with non-malignant HaCaT cells. Furthermore, compound 24 induced apoptosis in cancer cells and caused a decrease of mitochondrial membrane potential as well as an increase of cells in sub-G1 phase in contrast to its inactive analog 31. The strongest activity against the most sensitive HCT-116 cell line was found for compound 30 (IC50 = 8 uM), which was 11-fold more effective in the growth inhibition of HCT-116 cells than those of HaCaT cells. Based on this fact, the new derivatives may be promising leading structures for the search for agents for the treatment of colon cancer.
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Authors (5)
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Aneta Pogorzelska
- Gdański Uniwersytet Medyczny
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Jarosław Sławiński
- Gdański Uniwersytet Medyczny
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Anna Kawiak
- Uniwersytet Gdański, Gdański Uniwersytet Medyczny
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Grzegorz Stasiłojć
- Gdański Uniwersytet Medyczny
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- Accepted or Published Version
- DOI:
- Digital Object Identifier (open in new tab) 10.3390/ijms24054436
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- Category:
- Articles
- Type:
- artykuły w czasopismach
- Published in:
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INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
no. 24,
ISSN: 1661-6596 - Language:
- English
- Publication year:
- 2023
- Bibliographic description:
- Pogorzelska A., Sławiński J., Kawiak A., Stasiłojć G., Chojnacki J.: Synthesis of 3-(2-Alkylthio-4-chloro-5-methylbenzenesulfonyl)-2-(1-phenyl-3-arylprop-2-enylideneamino)guanidine Derivatives with Pro-Apoptotic Activity against Cancer Cells// INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES -Vol. 24,iss. 5 (2023), s.4436-
- DOI:
- Digital Object Identifier (open in new tab) 10.3390/ijms24054436
- Sources of funding:
-
- COST_FREE
- Verified by:
- Gdańsk University of Technology
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