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Synthesis, physicochemical and theoretical studies on new rhodium and ruthenium dimers. Relationship between structure and cytotoxic activity
Abstract
Two dimeric compounds of the general formulae (Et3NH)2[Rh2(μ2-L)4Cl2] (1) (where L = thiophene-2-carboxylate) and [((η6-p-cymene)Ru)2(μ-Cl)3]PF6 (2) have been synthesized using a new method. The unique anionic complex 1 (space group P bca) has octahedral coordination in which the equatorial positions are occupied by the oxygen atoms of four thiophene-2-carboxylates in a paddle wheel fashion. In complex 2 (space group ), each Ru(II) ion exhibits a pseudo-octahedral, three-legged piano-stool geometry. The electronic structure and absorption spectral features of 1 were also investigated by means of absorption spectroscopy (UV–Vis) and TD-DFT calculations. The biological studies of 1 and 2, such as cytotoxicity, lipophilicity and interactions with DNA and BSA, point on structure-cytotoxic activity relationship of obtained dimers. The results obtained via MTT, SRB assays, UV–Vis and CD spectroscopy, suggest that the rhodium dimer interacts with DNA via groove binding, whereas 2 binds to DNA via electrostatic interactions only. The effect of the dimeric complexes on the cytotoxicity of three human cancer lines, myelomonocytic leukaemia (MV-4-11), colon adenocarcinoma (LoVo) and breast adenocarcinoma (MCF-7), as well as on normal mice fibroblast cells (BALB/3T3), has been screened. Cisplatin was used as a reference drug. As a general observation, the properties reported in this paper suggest that the rhodium complex has considerable potential as an anticancer agent against myelomonocytic leukaemia (IC50 = 4.02 µM).
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Authors (7)
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Joanna Masternak dr
- Institute of Chemistry, Jan Kochanowski University in Kielce
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Agnieszka Gilewska
- Institute of Chemistry, Jan Kochanowski University in Kielce
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Oleksiy Khavryuchenko
- TMM LLC, Kyiv, Ukraine
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Joanna Wietrzyk
- Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Wrocław, Poland
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Trynda Justyna
- Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Wrocław, Poland
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Barbara Barszcz dr hab.
- Institute of Chemistry, Jan Kochanowski University in Kielce
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Details
- Category:
- Articles
- Type:
- artykuł w czasopiśmie wyróżnionym w JCR
- Published in:
-
POLYHEDRON
no. 154,
pages 263 - 274,
ISSN: 0277-5387 - Language:
- English
- Publication year:
- 2018
- Bibliographic description:
- Masternak J., Gilewska A., Kazimierczuk K., Khavryuchenko O., Wietrzyk J., Justyna T., Barszcz B.: Synthesis, physicochemical and theoretical studies on new rhodium and ruthenium dimers. Relationship between structure and cytotoxic activity// POLYHEDRON. -Vol. 154, (2018), s.263-274
- DOI:
- Digital Object Identifier (open in new tab) 10.1016/j.poly.2018.07.054
- Verified by:
- Gdańsk University of Technology
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