Therapeutic Potential of Multifunctional Derivatives of Cholinesterase Inhibitors

Maja Przybyłowska; Krystyna Dzierzbicka; Szyman Kowalski; Klaudia Chmielewska; Iwona Inkielewicz-Stępniak

doi:10.2174/1570159x19666201218103434

Therapeutic Potential of Multifunctional Derivatives of Cholinesterase Inhibitors

Abstract

The aim of this work is review of tacrine analogues from the last three years, which were not included in the latest review work, donepezil and galantamine hybrids from 2015 and rivastigmine derivatives from 2014. In this account we summarize the efforts toward the development and characterization of non-toxic inhibitors of cholinesterases based on mentioned drugs with various interesting additional properties such as antioxidant, decreasing beta-amyloid plaque aggregation, nitric oxide production, pro-inflammatory cytokines release, monoamine oxidase-B activity, cytotoxicity and oxidative stress in vitro and in animal model that classify these hybrids as potential multifunctional therapeutic agents for Alzheimer's disease. Moreover, herein, we have described the cholinergic hypothesis, mechanisms of neurodegeneration and current pharmacotherapy of Alzheimer's disease which is based on the restoration of cholinergic function through blocking enzymes that break down acetylcholine.

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Authors (5)

Maja Przybyłowska
Krystyna Dzierzbicka prof. dr hab. inż.
Szyman Kowalski
Klaudia Chmielewska
Iwona Inkielewicz-Stępniak
- Gdański Uniwersytet Medyczny

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Category:: Articles
Type:: artykuły w czasopismach
Published in:: Current Neuropharmacology no. 19, pages 1323 - 1344,
ISSN: 1570-159X
Language:: English
Publication year:: 2021
Bibliographic description:: Przybyłowska M., Dzierzbicka K., Kowalski S., Chmielewska K., Inkielewicz-Stępniak I.: Therapeutic Potential of Multifunctional Derivatives of Cholinesterase Inhibitors// Current Neuropharmacology -Vol. 19,iss. 8 (2021), s.1323-1344
DOI:: Digital Object Identifier (open in new tab) 10.2174/1570159x19666201218103434
Verified by:: Gdańsk University of Technology