Therapeutic Potential of Multifunctional Tacrine Analogues

Maja Przybyłowska; Kowalski Szymon; Krystyna Dzierzbicka; Iwona Inkielewicz-Stępniak

doi:10.2174/1570159x16666180412091908

Therapeutic Potential of Multifunctional Tacrine Analogues

Abstract

Tacrine is a potent inhibitor of cholinesterases (acetylcholinesterase and butyrylcholinesterase) that shows limiting clinical application by liver toxicity. In spite of this, analogues of tacrine are considered as a model inhibitor of cholinesterases in the therapy of Alzheimer’s disease. The interest in these compounds is mainly related to a high variety of their structure and biological properties. In the present review, we have described the role of cholinergic transmission and treatment strategies in Alzheimer’s disease as well as the synthesis and biological activity of several recently developed classes of multifunctional tacrine analogues and hybrids, which consist of a new paradigm to treat Alzheimer’s disease. We have also reported potential of these analogues in the treatment of Alzheimer’s diseases in various experimental systems.

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License: Copyright (2019 Bentham Science Publishers)

Keywords

MULTIFUNCTIONAL TACRINE ANALOGUES, TACRINE HYBRIDS, ALZHEIMER’S DISEASE, CHOLINERGIC TRANSMISSION, NEUROPROTECTIVE ACTIVITY, HEPATOPROTECTION.

Details

Category:: Articles
Type:: artykuły w czasopismach
Published in:: Current Neuropharmacology no. 17, pages 472 - 490,
ISSN: 1570-159X
Language:: English
Publication year:: 2019
Bibliographic description:: PRZYBYŁOWSKA M., Szymon K., Dzierzbicka K., Inkielewicz-Stępniak I.: Therapeutic Potential of Multifunctional Tacrine Analogues// Current Neuropharmacology -Vol. 17,iss. 5 (2019), s.472-490
DOI:: Digital Object Identifier (open in new tab) 10.2174/1570159x16666180412091908
Verified by:: Gdańsk University of Technology