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Abstract
Novel phosphorus and thiophosphorus tacrine derivatives were designed, synthesized and their biological activity and molecular modeling was investigated as a new potential anti-Alzheimer's disease (AD) agents. All new synthesized compound exhibited lower toxicity against neuroblastoma cell line (SH-SY5Y) in comparison with tacrine. Two analogues in the series, 7 and 9, demonstrated lack of cytotoxicity against hepatocellular cells (hepG2).
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Authors (6)
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Iwona Inkielewicz-Stępniak
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Szymon Kowalski mgr inż.
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- Category:
- Articles
- Type:
- artykuły w czasopismach
- Published in:
-
Medicinal Chemistry
no. 16,
pages 947 - 957,
ISSN: 1573-4064 - Language:
- English
- Publication year:
- 2020
- Bibliographic description:
- Przybyłowska M., Inkielewicz-Stępniak I., Kowalski S., Dzierzbicka K., Demkowicz S., Daśko M.: Synthesis and Cholinesterase Inhibitory Activity of N-Phosphorylated /N-Tiophosphorylated Tacrine// Medicinal Chemistry -Vol. 16,iss. 7 (2020), s.947-957
- DOI:
- Digital Object Identifier (open in new tab) 10.2174/1573406415666190716115524
- Verified by:
- Gdańsk University of Technology
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