TRF1 and TRF2: pioneering targets in telomere-based cancer therapy - Publication - Bridge of Knowledge

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TRF1 and TRF2: pioneering targets in telomere-based cancer therapy

Abstract

This article presents an in-depth exploration of the roles of Telomere Repeat-binding Factors 1 and 2 (TRF1 and TRF2), and the shelterin complex, in the context of cancer biology. It emphasizes their emerging significance as potential biomarkers and targets for therapeutic intervention. Central to the shelterin complex, TRF1 and TRF2 are crucial in maintaining telomere integrity and genomic stability, their dysregulation often being a hallmark of cancerous cells. The article delves into the diagnostic and prognostic capabilities of TRF1 and TRF2 across various cancer types, highlighting their sensitivity and specificity. Furthermore, it reviews current strides in drug discovery targeting the shelterin complex, detailing specific compounds and their modes of action. The review candidly addresses the challenges in developing therapies aimed at the shelterin complex, including drug resistance, off-target effects, and issues in drug delivery. By synthesizing recent research findings, the article sheds light on the intricate relationship between telomere biology and cancer development. It underscores the urgency for continued research to navigate the existing challenges and fully leverage the therapeutic potential of TRF1, TRF2, and the shelterin complex in the realm of cancer treatment.

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Category:
Articles
Type:
artykuły w czasopismach
Published in:
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY no. 150,
ISSN: 0171-5216
Language:
English
Publication year:
2024
Bibliographic description:
Kallingal A., Krzemieniecki R., Maciejewska N., Brankiewicz-Kopcinska W., Bagiński M.: TRF1 and TRF2: pioneering targets in telomere-based cancer therapy// JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY -,iss. 7 (2024),
DOI:
Digital Object Identifier (open in new tab) 10.1007/s00432-024-05867-3
Sources of funding:
  • Free publication
Verified by:
Gdańsk University of Technology

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