Search results for: HUMAN CYP ISOENZYMES

• Mechanism-based inactivation of human cytochrome P450 1A2 and 3A4 isoenzymes by antitumor triazoloacridinone C-1305.

  Publication

  • A. Potęga
  • B. Fedejko-kap
  • Z. Mazerska

  - XENOBIOTICA - Year 2016

  5-Dimethylaminopropylamino-8-hydroxytriazoloacridinone, C-1305, is a promising antitumor therapeutic agent with high activity against several experimental tumors. It was determined to be a potent and selective inhibitor of liver microsomal and human recombinant cytochrome P450 (CYP) 1A2 and 3A4 isoenzymes. Therefore, C-1305 might modulate the effectiveness of other drugs used in multidrug therapy. The objective of this study was...

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• Imidazoacridinone antitumor agent C-1311 as a selective mechanism- based inactivator of human cytochrome P450 1A2 and 3A4 isoenzymes.

  Publication

  • A. Potęga
  • B. Fedejko-kap
  • Z. Mazerska

  - Pharmacological Reports - Year 2016

  5-Diethylaminoethylamino-8-hydroxyimidazoacridinone (C-1311), a promising antitumor agent that is also active against autoimmune diseases, was determined to be a selective inhibitor of the cytochrome P450 (CYP) 1A2 and 3A4 isoenzymes. Therefore, C-1311 might modulate the effectiveness of other drugs used in multidrug therapy. The present work aimed to identify the mechanism of the observed C-1311-mediated inactivation of CYP1A2...

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• Non-enzymatic glutathione-mediated conjugation of unsymmetrical bisacridine C-2028 with anticancer activity

  Open Research Data

  open access

  • A. Potęga
  • D. Rafalska
  • E. Paluszkiewicz
  • K. Kozłowska-Tylingo

  The presented data complement the studies on the interplay between C-2028 (anticancer-active unsymmetrical bisacridine) and the glutathione S-transferase/glutathione (GST/GSH) system.

• Robotics for human health and performance 03.2022

  e-Learning Courses

  • W. Sieklicki

  This course is to provide knowledge in area of biomechanics, necessary to design instrumentation for human health and performance, and automatics necessary to design simple instrumentation as well as about human-robot interface.

• Robotics for human health and performance (PG_00054982) 04.2024

  e-Learning Courses

  • W. Sieklicki

  During this course students will be provided with the knowledge in areas of robotics and biomechanics necessary to design instrumentation for human health and performance, as well as about human-robot interface.

• Marcin Sikorski prof. dr hab. inż.

  People

  Department of Informatics in Management

  Marcin Sikorski is a professor at the Department of Informatics in Management at the Faculty of Management and Economics of the Gdańsk University of Technology. Earlier he had numerous fellowships in academic institutions, among others in Germany (Universities in Bonn and in Heidelberg), Switzerland (ETH Zurich), the Netherlands (TU Eindhoven) and the USA (Harvard University). Professor Sikorski is a representative of Poland in...

• Human Computer Interaction

  e-Learning Courses

  • T. Kocejko

• The studies of imidazoacridinone antitumor agent, C-1311, in the field of metabolic transformations with cytochrome P450 isoenzymes

  Publication

  • A. Chrapkowska
  • E. Piątek
  • A. Wiśniewska
  • J. Konopa
  • Z. Mazerska

  - Acta Biochimica Polonica - Year 2006

  Praca zawiera wyniki badań metabolicznej transformacji przeciwnowotworowej pochodnej imidazoakrydonu C-1311 wobec rekombinantowych ludzkich izoenzymów P450. Związek nie ulegał transformacji w badanych warunkach, natomiast wykazano, że ma zdolność hamowania aktywności izoezymów CYP1A2 i CYP3A4.

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• Nanotechnology and human environment

  e-Learning Courses

  • M. Chmielewski

• Advances in Human Genetics

  e-Learning Courses

  • A. Stanisławska-Sachadyn