Search results for: THIOMALONOAMIDE - Bridge of Knowledge

Search results for: THIOMALONOAMIDE

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Peptide modification with thiomalonoamide moiety
Publication
- K. Janikowska
- S. Makowiec
- Year 2011
Abstract: Meldrum acid derivatives under the thermal decomposition are well known source of ketenes. Recently we investigated chemical properties of thiocarbamolyl meldrum acids. We found that 5-(α-alkylamino- α'-sulfhydryl)methylene Meldrum's acids hated in the presence of amines produce thiomalonamides. We used this reaction to the one pot synthesis of series of short peptides containing thiomalonoamide motif.