Search results for: THIOMALONOAMIDE - Bridge of Knowledge

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Search results for: THIOMALONOAMIDE

Search results for: THIOMALONOAMIDE

  • Peptide modification with thiomalonoamide moiety

    Publication

    Abstract: Meldrum acid derivatives under the thermal decomposition are well known source of ketenes. Recently we investigated chemical properties of thiocarbamolyl meldrum acids. We found that 5-(α-alkylamino- α'-sulfhydryl)methylene Meldrum's acids hated in the presence of amines produce thiomalonamides. We used this reaction to the one pot synthesis of series of short peptides containing thiomalonoamide motif.