Wyniki wyszukiwania dla: THIOMALONOAMIDE

• Peptide modification with thiomalonoamide moiety

  Publikacja

  • K. Janikowska
  • S. Makowiec

  - Rok 2011

  Abstract: Meldrum acid derivatives under the thermal decomposition are well known source of ketenes. Recently we investigated chemical properties of thiocarbamolyl meldrum acids. We found that 5-(α-alkylamino- α'-sulfhydryl)methylene Meldrum's acids hated in the presence of amines produce thiomalonamides. We used this reaction to the one pot synthesis of series of short peptides containing thiomalonoamide motif.