Search results for: Quantum dots

• pH-Responsive Drug Delivery Nanoplatforms as Smart Carriers of Unsymmetrical Bisacridines for Targeted Cancer Therapy

  Publication

  • J. Pilch
  • A. Potęga
  • A. Kowalczyk
  • A. Kasprzak
  • P. Kowalik
  • P. Bujak
  • E. Paluszkiewicz
  • E. Augustin
  • A. M. Nowicka

  - Pharmaceutics - Year 2023

  Selective therapy and controlled drug release at an intracellular level remain key challenges for effective cancer treatment. Here, we employed folic acid (FA) as a self-navigating molecule in nanoconjugates containing quantum dots (QDs) and β-cyclodextrin (β-CD) for the delivery of antitumor unsymmetrical bisacridine compound (C-2028) to lung and prostate cancers as well as normal cells. The bisacridine derivative can form the...

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• Acid–Base Equilibrium and Self-Association in Relation to High Antitumor Activity of Selected Unsymmetrical Bisacridines Established by Extensive Chemometric Analysis

  Publication

  • M. Kosno
  • T. Laskowski
  • J. Frąckowiak
  • A. Potęga
  • A. Kurdyn
  • W. Andrałojć
  • J. Borzyszkowska-Bukowska
  • K. Szwarc-Karabyka
  • Z. Mazerska

  - MOLECULES - Year 2022

  Unsymmetrical bisacridines (UAs) represent a novel class of anticancer agents previously synthesized by our group. Our recent studies have demonstrated their high antitumor potential against multiple cancer cell lines and human tumor xenografts in nude mice. At the cellular level, these compounds affected 3D cancer spheroid growth and their cellular uptake was selectively modulated by quantum dots. UAs were shown to undergo metabolic...

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