Search results for: CHEMOSENSITIZATION

• Chemosensitization of multidrug resistant Candida albicans by the oxathiolone fused chalcone derivatives

  Publication

  • I. Ła̧cka
  • M. T. Konieczny
  • A. Bułakowska
  • M. Kodedová
  • D. Gašková
  • I. Maurya
  • R. Prasad
  • S. Milewski

  - Frontiers in Microbiology - Year 2015

  Three structurally related oxathiolone fused chalcone derivatives appeared effective chemosensitizers, able to restore in part sensitivity to fluconazole of multidrug-resistant C.albicans strains. Compound 21 effectively chemosensitized cells resistant due to the overexpression of the MDR1 gene, compound 6 reduced resistance of cells overexpressing the ABC-type drug transporters CDR1/CDR2 and derivative 18 partially reversed fluconazole...

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