Search results for: CHEMOSENSITIZATION - Bridge of Knowledge

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Search results for: CHEMOSENSITIZATION

Search results for: CHEMOSENSITIZATION

  • Chemosensitization of multidrug resistant Candida albicans by the oxathiolone fused chalcone derivatives

    Publication
    • I. Ła̧cka
    • M. T. Konieczny
    • A. Bułakowska
    • M. Kodedová
    • D. Gašková
    • I. Maurya
    • R. Prasad
    • S. Milewski

    - Frontiers in Microbiology - Year 2015

    Three structurally related oxathiolone fused chalcone derivatives appeared effective chemosensitizers, able to restore in part sensitivity to fluconazole of multidrug-resistant C.albicans strains. Compound 21 effectively chemosensitized cells resistant due to the overexpression of the MDR1 gene, compound 6 reduced resistance of cells overexpressing the ABC-type drug transporters CDR1/CDR2 and derivative 18 partially reversed fluconazole...

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