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Chemosensitization of multidrug resistant Candida albicans by the oxathiolone fused chalcone derivatives
Abstract
Three structurally related oxathiolone fused chalcone derivatives appeared effective chemosensitizers, able to restore in part sensitivity to fluconazole of multidrug-resistant C.albicans strains. Compound 21 effectively chemosensitized cells resistant due to the overexpression of the MDR1 gene, compound 6 reduced resistance of cells overexpressing the ABC-type drug transporters CDR1/CDR2 and derivative 18 partially reversed fluconazole resistance mediated by both types of yeast drug efflux pumps. The observed effect of sensitization of resistant strains of Candida albicans to fluconazole activity in the presence of active compounds most likely resulted from inhibition of the pump-mediated efflux, as was revealed by the results of studies involving the fluorescent probes, Nile Red, Rhodamine 6G and diS-C3(3).
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Authors (8)
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Marek T. Konieczny
- Wydział Farmaceutyczny z Oddziałem Medycyny Laboratoryjnej GUMed Katedra Chemii Organicznej
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Anita Bułakowska
- Wydział Farmaceutyczny z Oddziałem Medycyny Laboratoryjnej GUMed Katedra Chemii Organicznej
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Marie Kodedová
- Faculty of Mathematics and Physics, Charles University in Prague, Czech Republic School of Physics
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Dana Gašková
- Faculty of Mathematics and Physics, Charles University in Prague, Czech Republic School of Physics
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Indresh Maurya
- School of Life Sciences, JNU, New Delhi, India Membrane Biology Laboratory
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Rajendra Prasad
- School of Life Sciences, JNU, New Delhi, India Membrane Biology Laboratory
Cite as
Full text
- Publication version
- Accepted or Published Version
- DOI:
- Digital Object Identifier (open in new tab) 10.3389/fmicb.2015.00783
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Details
- Category:
- Articles
- Type:
- artykuł w czasopiśmie wyróżnionym w JCR
- Published in:
-
Frontiers in Microbiology
no. 6,
ISSN: 1664-302X - Language:
- English
- Publication year:
- 2015
- Bibliographic description:
- Ła̧cka I., Konieczny M. T., Bułakowska A., Kodedová M., Gašková D., Maurya I., Prasad R., Milewski S.: Chemosensitization of multidrug resistant Candida albicans by the oxathiolone fused chalcone derivatives// Frontiers in Microbiology. -Vol. 6, (2015), s.783-
- DOI:
- Digital Object Identifier (open in new tab) 10.3389/fmicb.2015.00783
- Verified by:
- Gdańsk University of Technology
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