Search results for: INTEGRIN ΑVΒ3

• Synthesis, Chemical Characterization and Multiscale Biological Evaluation of a dimericcRGD Peptide for Targeted Imaging of αVβ3 Integrin Activity

  Publication

  • J. Hedhli
  • A. Czerwiński
  • M. Schuelke
  • A. Płoska
  • P. Sowiński
  • L. La Hood
  • S. B. Mamer
  • J. A. Cole
  • P. Czaplewska
  • M. Banach... and 4 others

  - Scientific Reports - Year 2017

  Cyclic peptides containing the Arg-Gly-Asp (RGD) sequence have been shown to specifically bind the angiogenesis biomarker α V β3 integrin. We report the synthesis, chemical characterization, and biological evaluation of two novel dimeric cyclic RGD-based molecular probes for the targeted imaging of α V β3 activity (a radiolabeled version, 64Cu-NOTA-PEG4-cRGD2, for PET imaging, and a fluorescent version, FITC-PEG4-cRGD2, for in...

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• 99mTc-Galacto-RGD2: A Novel 99mTc-Labeled Cyclic RGD Peptide Dimer Useful for Tumor Imaging

  Publication

  • S. Ji
  • A. Czerwiński
  • Y. Zhou
  • G. Shao
  • F. Valenzuela
  • P. Sowiński
  • S. Chauhan
  • M. Pennington
  • S. Liu

  - MOLECULAR PHARMACEUTICS - Year 2013

  This study sought to evaluate [99mTc(HYNIC-Galacto-RGD2)-(tricine)(TPPTS)] (99mTc-Galacto-RGD2: HYNIC = 6-hydrazinonicotinyl; Galacto-RGD2 = Glu[cyclo[Arg-Gly-Asp-D-Phe-Lys(SAA-PEG2-(1,2,3-triazole)-1-yl-4-ethylamide)]]2 (SAA = 7-amino-L-glycero-L-galacto-2,6-anhydro-7-eoxyheptanamide, and PEG2 = 3,6-dioxaoctanoic acid); and TPPTS = trisodium triphenylphosphine-3,3',3''-trisulfonate) as a new radiotracer for tumor imaging. Galacto-RGD2...

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