Search results for: KOMÓRKI PIERWOTNE NOWOTWORU

• Komórki macierzyste nowotworu i ich znaczenie w diagnostyce i terapii przeciwnowotworowej

  Publication

  • M. Serocki
  • A. Składanowski

  - Year 2012

  Według klasycznej teorii karcinogenezy nowotwór powstaje w wyniku ekspansji klonalnej pojedynczej komórki, która uległa transformacji w wyniku nagromadzenia się w jej genomie zmian genetycznych i epigenetycznych. Jednak w ostatnich latach przywołano do życia inną hipotezę, przedstawioną już ponad 150 lat temu, która mówi, że nowotwór wywodzi się ze stransformowanych komórek posiadających cechy komórek pierwotnych (macierzystych)....

• Ewa Augustin dr hab.

  People

  Department of Pharmaceutical Technology and Biochemistry

• Cancer stem cells and escape from drug-induced premature senescence in human lung tumor cells: implications for drug resistance and in vitro drug screening models

  Publication

  • M. Sabisz
  • A. Składanowski

  - CELL CYCLE - Year 2009

  Badania z użyciem modelu komórek nowotworu płuc A549 wykazały, że komórki te po traktowaniu lekami uszkadzającymi DNA zatrzymują proliferację i wchodzą w stan starzenia komórkowego. Jednak post-inkubacja tych komórek prowadzi do powrotu do stanu proliferacji małej frakcji komórek. Wykazaliśy, że frakcja ta związana jest z obecnością komórek pierwotnych nowotworu w populacji komórek A549. Powrót do stanu proliferacji komóek A549...

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• Morphological and cellular alternations of HepG2 cells overexpressing CYP3A4 after treatment with antitumor imidazoacridinone derivative C-1311

  Publication

  • E. Augustin
  • J. Polewska
  • M. Demusiak
  • J. Konopa

  - Folia Histochemica et Cytobiologica - Year 2008

  W pracy badano odpowiedź biologiczną komórek nowotworu wątroby HepG2 z nadekspresją izoenzymu CYP3A4 pod wpływem pochodnej imidazoakrydonu C-1311. Wyniki porównywano z odpowiedzią komórek HepG2 z tzw. wektorem zerowym.Izoeznym CYP3A4 jest jednym z izoenzymów cytochromu P450 odpowiedzialnych za przemiany metaboliczne pochodnej C-1311. Wykazano, że pochodna C-1311 indukuje w obu liniach komórkowych blok w fazie G2/M cyklu komórkowego,...

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• From chemoresistance to cancer stem cells: the case of BRCP/ABCG2 half transporter

  Publication

  • A. Składanowski

  - Acta Biochimica Polonica - Year 2007

  Ludzkie białko ABCG2 jest pompą typu ABC tworzącą homodimery i aktywnie transportującą leki i inne substraty naturalne i syntetyczne. Nadekspresja tego białko prowadzi do oporności na leki przeciwnowotworowe. Białko ABCG2 występuje w wielu formach zmutowanych, różniących się własnościami substratowymi, stąd istotne dla oporności na leki jest jaka forma genu i białka ABCG2 ulega nadekspresji w komórce. Ostatnie badania wskazują,...

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• Odpowiedź komórkowa indukowana przez niesymetryczne bisakrydyny skoniugowane z nanocząstkami w komórkach ludzkich raków okrężnicy i płuc

  Publication

  • J. Pilch

  - Year 2021

  Pomimo znaczącego postępu w terapii nowotworów, wciąż pozostają one drugą przyczyną umieralności na świecie. Związane jest to przede wszystkim z brakiem istotnych różnic pomiędzy komórkami nowotworowymi a prawidłowymi, co przekłada się na problemy z terapią. Ponadto, chemioterapia często związana jest z dystrybucją silnie toksycznych związków, w dawkach które mogą powodować niespecyficzne działanie leku. W celu podniesienia specyficzności...

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• Anaplastic large cell lymphoma, ALK negative - Female, 86 - Tissue image [9230729557255281]

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  • Gdański Uniwersytet Medyczny

  This is the histopathological image of UNKNOWN PRIMARY SITE tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• Anaplastic large cell lymphoma, ALK negative - Female, 86 - Tissue image [9230729557259031]

  Open Research Data

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of UNKNOWN PRIMARY SITE tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• Anaplastic large cell lymphoma, ALK negative - Female, 86 - Tissue image [9230729557253751]

  Open Research Data

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of UNKNOWN PRIMARY SITE tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• Anaplastic large cell lymphoma, ALK negative - Female, 86 - Tissue image [9230729557258581]

  Open Research Data

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  • Gdański Uniwersytet Medyczny

  This is the histopathological image of UNKNOWN PRIMARY SITE tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• Anaplastic large cell lymphoma, ALK negative - Female, 86 - Tissue image [9230729557253151]

  Open Research Data

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  • Gdański Uniwersytet Medyczny

  This is the histopathological image of UNKNOWN PRIMARY SITE tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• Anaplastic large cell lymphoma, ALK negative - Female, 86 - Tissue image [3300730069444061]

  Open Research Data

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of UNKNOWN PRIMARY SITE tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• Anaplastic large cell lymphoma, ALK negative - Female, 86 - Tissue image [9230729557253131]

  Open Research Data

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of UNKNOWN PRIMARY SITE tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• Anaplastic large cell lymphoma, ALK negative - Female, 86 - Tissue image [9230729557258901]

  Open Research Data

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of UNKNOWN PRIMARY SITE tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• Anaplastic large cell lymphoma, ALK negative - Female, 86 - Tissue image [9230729557255031]

  Open Research Data

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of UNKNOWN PRIMARY SITE tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• Anaplastic large cell lymphoma, ALK negative - Female, 86 - Tissue image [9230729557252291]

  Open Research Data

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of UNKNOWN PRIMARY SITE tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• Anaplastic large cell lymphoma, ALK negative - Female, 86 - Tissue image [9230729557251451]

  Open Research Data

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of UNKNOWN PRIMARY SITE tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• Rak trzustki – przyczyny oporności na chemioterapię

  Publication

  • B. Borowa-Mazgaj

  - Postępy Higieny i Medycyny Doświadczalnej - Year 2016

  Mimo ogromnego postępu jaki dokonał się w ciągu ostatnich dekad w diagnostyce, leczeniu i zapobieganiu wielu typom nowotworów, współczynnik przeżywalności w przypadku raka trzustki nadal pozostaje bardzo niski. Rak trzustki należy do bardzo źle rokujących i opornych na leczenie nowotworów. Wynika to w głównej mierze z braku skutecznej diagnostyki na wczesnym etapie rozwoju nowotworu oraz nieefektywnej terapii. U większości pacjentów...

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• Superficial spreading melanoma - Female, 37 - Tissue image [10040729541219041]

  Open Research Data

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  • Gdański Uniwersytet Medyczny

  This is the histopathological image of UNKNOWN PRIMARY SITE tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• Superficial spreading melanoma - Female, 37 - Tissue image [10040729541219121]

  Open Research Data

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of UNKNOWN PRIMARY SITE tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• Superficial spreading melanoma - Female, 37 - Tissue image [3300730069441861]

  Open Research Data

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of UNKNOWN PRIMARY SITE tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• Classical Hodgkin lymphoma, mixed cellularity, NOS - Female, 23 - Tissue image [9270729565555711]

  Open Research Data

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of UNKNOWN PRIMARY SITE tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• Classical Hodgkin lymphoma, mixed cellularity, NOS - Female, 23 - Tissue image [9270729565551921]

  Open Research Data

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of UNKNOWN PRIMARY SITE tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• Classical Hodgkin lymphoma, mixed cellularity, NOS - Female, 23 - Tissue image [9270729565552591]

  Open Research Data

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of UNKNOWN PRIMARY SITE tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• Classical Hodgkin lymphoma, mixed cellularity, NOS - Female, 23 - Tissue image [9270729565558071]

  Open Research Data

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of UNKNOWN PRIMARY SITE tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• Classical Hodgkin lymphoma, mixed cellularity, NOS - Female, 23 - Tissue image [9270729565557231]

  Open Research Data

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of UNKNOWN PRIMARY SITE tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• Classical Hodgkin lymphoma, mixed cellularity, NOS - Female, 23 - Tissue image [9270729565558951]

  Open Research Data

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of UNKNOWN PRIMARY SITE tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• Classical Hodgkin lymphoma, mixed cellularity, NOS - Female, 23 - Tissue image [9270729565553851]

  Open Research Data

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of UNKNOWN PRIMARY SITE tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• Classical Hodgkin lymphoma, mixed cellularity, NOS - Female, 23 - Tissue image [9270729565558541]

  Open Research Data

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of UNKNOWN PRIMARY SITE tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• Classical Hodgkin lymphoma, mixed cellularity, NOS - Female, 23 - Tissue image [9270729565552641]

  Open Research Data

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of UNKNOWN PRIMARY SITE tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• Classical Hodgkin lymphoma, mixed cellularity, NOS - Female, 23 - Tissue image [9270729565558491]

  Open Research Data

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of UNKNOWN PRIMARY SITE tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• Myxoid liposarcoma - Male, 48 - Tissue image [9200729571531111]

  Open Research Data

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of UNKNOWN PRIMARY SITE tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• Myxoid liposarcoma - Male, 48 - Tissue image [9200729571537281]

  Open Research Data

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of UNKNOWN PRIMARY SITE tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• Myxoid liposarcoma - Male, 48 - Tissue image [9200729571538401]

  Open Research Data

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of UNKNOWN PRIMARY SITE tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• Solitary fibrous tumor, NOS - Male, 59 - Tissue image [10040729541216751]

  Open Research Data

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of UNKNOWN PRIMARY SITE tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• Solitary fibrous tumor, NOS - Male, 59 - Tissue image [3300730069441211]

  Open Research Data

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of UNKNOWN PRIMARY SITE tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• Leiomyosarcoma, NOS - Female, 53 - Tissue image [10090730022505591]

  Open Research Data

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of UNKNOWN PRIMARY SITE tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• Leiomyosarcoma, NOS - Female, 53 - Tissue image [10090730022509611]

  Open Research Data

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of UNKNOWN PRIMARY SITE tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• Solitary fibrous tumor, NOS - Male, 59 - Tissue image [10040729541211971]

  Open Research Data

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of UNKNOWN PRIMARY SITE tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• Solitary fibrous tumor, NOS - Male, 59 - Tissue image [10040729541218291]

  Open Research Data

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of UNKNOWN PRIMARY SITE tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• Myxoid liposarcoma - Male, 48 - Tissue image [9200729571533411]

  Open Research Data

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of UNKNOWN PRIMARY SITE tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• Leiomyosarcoma, NOS - Female, 71 - Tissue image [10090730022503641]

  Open Research Data

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of UNKNOWN PRIMARY SITE tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• Glomus tumor, NOS - Female, 52 - Tissue image [10040729541216941]

  Open Research Data

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  • Gdański Uniwersytet Medyczny

  This is the histopathological image of UNKNOWN PRIMARY SITE tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• Leiomyosarcoma, NOS - Female, 71 - Tissue image [10090730022507291]

  Open Research Data

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of UNKNOWN PRIMARY SITE tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• Leiomyosarcoma, NOS - Male, 57 - Tissue image [10090730022505981]

  Open Research Data

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of UNKNOWN PRIMARY SITE tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• Leiomyosarcoma, NOS - Male, 57 - Tissue image [10090730022507641]

  Open Research Data

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of UNKNOWN PRIMARY SITE tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• Leiomyosarcoma, NOS - Male, 57 - Tissue image [10090730022504061]

  Open Research Data

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of UNKNOWN PRIMARY SITE tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• Leiomyosarcoma, NOS - Male, 57 - Tissue image [3300730069431331]

  Open Research Data

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of UNKNOWN PRIMARY SITE tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• Leiomyosarcoma, NOS - Female, 71 - Tissue image [10090730022506011]

  Open Research Data

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of UNKNOWN PRIMARY SITE tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• Mantle cell lymphoma - Female, 37 - Tissue image [9090729594402791]

  Open Research Data

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of UNKNOWN PRIMARY SITE tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.