Search results for: LINEAGE SWITCH

• Immune escape of B-cell lymphoblastic leukemic cells through a lineage switch to acute myeloid leukemia

  Publication

  • K. Bełdzińska-Gądek
  • E. Zarzycka
  • K. Pastuszak
  • K. Borman
  • K. Lewandowski
  • J. M. Zaucha
  • W. Prejzner

  - LEUKEMIA & LYMPHOMA - Year 2024

  Acute leukemia (AL) with a lineage switch (LS) is associated with poor prognosis. The predisposing factors of LS are unknown, apart from KMT2A rearrangements that have been reported to be associated with LS. Herein, we present two cases and review all 104 published cases to identify risk factors for LS. Most of the patients (75.5%) experienced a switch from the lymphoid phenotype to the myeloid phenotype. Eighteen patients (17.0%)...

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