Search results for: RESSISTANCE MECHANISM

• Transport deficiency is the molecular basis of Candida albicans resistance to antifungal oligopeptides

  Publication

  • M. Schielmann
  • P. Szweda
  • K. M. Gucwa
  • M. Kawczyński
  • M. J. Milewska
  • D. Martynow
  • J. Morschhauser
  • S. Milewski

  - Frontiers in Microbiology - Year 2017

  (FMDP), an inhibitor of glucosamine-6-phosphate synthase, exhibited growth inhibitory activity against Candida albicans, with minimal inhibitory concentration values in the 0.05–50 mg/L range. Uptake by the peptide permeases was found to be the main factor limiting an anticandidal activity of these compounds. Di- and tripeptide containing FMDP (F2 and F3) were transported by Ptr2p/Ptr22p peptide transporters (PTR) and FMDP-containing...

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