Search results for: RESVERATROL UDP-GLUCURONYLTRANSFERASES SYNTHETIC STILBENOIDS

• Novel Resveratrol-Based Substrates for Human Hepatic, Renal, and Intestinal UDP-Glucuronosyltransferases

  Publication

  • A. K. Greer
  • N. R. Madadi
  • S. M. Bratton
  • S. D. Eddy
  • Z. Mazerska
  • H. P. Hendrikcson
  • P. A. Crooks
  • A. Radominska-Pandya

  - CHEMICAL RESEARCH IN TOXICOLOGY - Year 2014

  Trans-Resveratrol (tRes) has been shown to have powerful antioxidant, anti-inflammatory, anti-carcinogenic, and anti-aging properties; however, its use as a therapeutic agent is limited by its rapid metabolism into its conjugated forms by UDP-Glucuronosyltransferases (UGTs). The aim of the current study was to test the hypothesis that the limited bioavailability of tRes can be improved by modifying its structure to create analogs...

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• Biotransformation of abused synthetic cannabinoids, JWH-018 and JWH-073, by human cytochromes P450 and UDP-glucuronosyltransferases

  Publication

  • A. Radominska-Pandya
  • K. C. Chimalakonda
  • S. M. Bratton
  • B. Fedejko-Kap
  • V. Le
  • K. H. Yiew
  • C. Moran
  • L. P. James
  • J. H. Moran

  - DRUG METABOLISM REVIEWS - Year 2011

  Związki oznaczone symbolami JWH-018 i JWH-073 są syntetycznymi pochodnymi kanabinoidów, obecnymi w preparatach o działaniu psychoaktywnym (K2/Spice). Wcześniejsze badań wykazały, że u osób przyjmujących tzw. ''legalną marihuanę'', głównymi produktami biotransformacji obecnymi w moczu były hydroksylowe pochodne obu związków, jak również ich glukuronidy. W związku z tym celem prowadzonych badań było określenie roli poszczególnych...

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• The II phase metabolism of endogenous and exogenous compounds, including antitumor chemotherapeutics

  Publication

  • Z. Mazerska
  • A. Mróz
  • A. Bejrowska
  • B. Borowa-Mazgaj
  • A. Potęga
  • E. Augustin

  - Year 2014

  The II phase metabolism, it is a set of metabolism and excretion pathways of endogenous as well as exogenous compounds including xenobiotics. UDP-glucuronyltransferases (UGTs; EC 2.4.1.17) are the most crucial representatives of II phase enzymes, which are responsible for the transformation of bilirubine and bile acids, steroids and thyroid hormones and lipids. Exogenous compounds, including drugs, carcinogens, environmental pollutants...