Search results for: BENZOHYDROXAMIC ACID

• Cytotoxic and Antioxidant Activities of Benzohydroxamic Acid Analogues

  Publication

  • W. Przychodzeń
  • J. Nycz

  - BULLETIN OF THE KOREAN CHEMICAL SOCIETY - Year 2013

  20 benzohydroxamic acid analogues were synthesized and evaluated for their in vitro cytotoxicities against mouse mammary tumor cells as well as antioxidant activities against DPPH radical and superoxide anion. It was found that benzothiohydroxamic acids exhibit greater cytotoxicities than benzohydroxamic acids and N-isopropyl derivatives are more active than N-methyl ones. On the other hand, benzothiohydroxamic acids show more...

  Full text to download in external service

• Unexpected Z/E isomerism of N-methyl-O-phosphothioyl benzohydroxamic acids, their oxyphilic reactivity and inertness to amines

  Publication

  • A. Majewski
  • J. Chojnacki
  • W. Przychodzeń

  - STRUCTURAL CHEMISTRY - Year 2021

  Thiophosphinoylation of N-methyl p-substituted benzohydroxamic acids using disulfanes (method A) or diphenylphosphinothioyl chloride (method B) provides only one conformer of the respective O-phosphothioyl derivative (Xray and NMR analysis). Undergoing the P-transamidoxylation reaction is an evidence of the reversibility of thiophosphinoylation. Only those products containing strong EWG substituents in the aroyl residue or bulky...

  Full text available to download

• AMINO ACIDS

  Journals

  ISSN: 0939-4451 , eISSN: 1438-2199

• NUCLEIC ACIDS RESEARCH

  Journals

  ISSN: 0305-1048 , eISSN: 1362-4962

• Nucleic Acid Therapeutics

  Journals

  ISSN: 2159-3337 , eISSN: 2159-3345

• Matcha Green Tea: Chemical Composition, Phenolic Acids, Caffeine and Fatty Acid Profile

  Publication

  • J. Kika
  • K. Jakubczyk
  • A. Ligenza
  • D. Maciejewska-Markiewicz
  • K. Szymczykowska
  • K. Janda-Milczarek

  - Foods - Year 2024

  Full text to download in external service

• Arid Ecosystems

  Journals

  ISSN: 2079-0961 , eISSN: 2079-0988

• Synthesis and biological activity of mycophenolic acid-amino acid derivatives

  Publication

  • D. Iwaszkiewicz-Grześ
  • G. Cholewiński
  • A. Kot-Wasik
  • P. Trzonkowski
  • K. Dzierzbicka

  - EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY - Year 2013

  In search of new immunosuppressants, mycophenolic acid (MPA) was coupled with amino acid methyl esters followed by hydrolysis to analogs bearing free carboxylic groups. The obtained compunds were tested in vitro as growth inhibitors of lymphoid cell line (Jurkat) and human peripheral blood mononuclear cells (PBMC) from healthy donors. According to obtained results recovering of free carboxylic group increased their activity. Additionally,...

  Full text available to download

• Synthesis and biological activity of mycophenolic acid-amino acid derivatives

  Publication

  • D. Iwaszkiewicz-Grzes
  • G. Cholewinski
  • A. Kot-Wasik
  • P. Trzonkowski
  • K. Dzierzbicka

  - EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY - Year 2013

  Full text to download in external service

• Anticancer Properties of Amino Acid and Peptide Derivatives of Mycophenolic Acid

  Publication

  • A. Siebert
  • M. Deptuła
  • M. Cichorek
  • A. Ronowska
  • G. Cholewiński
  • J. Rachoń

  - Anti-Cancer Agents in Medicinal Chemistry - Year 2021

  Background: Although Mycophenolic Acid (MPA) is applied as prodrugs in clinic as an immunosuppressant, it also possesses anticancer activity. MPA acts as Inosine-5’-Monophosphate Dehydrogenase (IMPDH) inhibitor, where the carboxylic group at the end of the side chain interacts with Ser 276 of the enzyme via hydrogen bonds. Therefore, MPA derivatives with other polar groups indicated high inhibition too. On the other hand, potent...

  Full text available to download