Search results for: DRUGS DOSAGE

• Disposition of Drugs of Abuse and Their Metabolites in Wastewater as a Method of the Estimation of Drug Consumption

  Publication

  • E. Daghir
  • M. J.

  - Current Drug Metabolism - Year 2010

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• Methods for Elucidation of DNA-Anticancer Drug Interactions and Their Applications in the Development of New Drugs

  Publication

  • M. Misiak
  • F. Mantegazza
  • G. Beretta

  - CURRENT PHARMACEUTICAL DESIGN - Year 2016

  DNA damaging agents including anthracyclines, camptothecins and platinum drugs are among most frequently used drugs in the chemotherapeutic routine. Due to their relatively low selectivity for cancer cells, administration is associated with adverse side effects, whereas the inherent genotoxicity of these drugs is associated with risk of developing secondary cancers. Development of new drugs, which could be spared of these drawbacks...

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• Optical properties of the chemotherapy drugs used in the central nervous system lymphoma therapy: monitoring drug delivery

  Publication

  • T. Myllylä
  • A. P. Popov
  • Ł. Surażyński
  • J. Oinas
  • O. Bibikova
  • A. Bykov
  • M. Wróbel
  • M. Gnyba
  • M. Szczerska
  • I. Meglinski
  • O. Kuittinen

  - Year 2015

  Our aim is to optically monitor the delivery of the chemotherapy drugs for brain tumours, particularly used in the central nervous system (CNS) lymphoma therapy. In vivo monitoring would help to optimize the treatment and avoiding unnecessary medications. Moreover, it would be beneficial to be able to measure which of the multi-regimen drugs actually do penetrate and how well into the brain tissue. There exist several potential...

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• Glutathione-mediated conjugation of anticancer drugs: an overview of reaction mechanisms and biological significance for drug detoxification and bioactivation.

  Publication

  • A. Potęga

  - MOLECULES - Year 2022

  The effectiveness of many anticancer drugs depends on the creation of specific metabolites that may alter their therapeutic or toxic properties. One significant route of biotransformation is a conjugation of electrophilic compounds with reduced glutathione, which can be non-enzymatic and/or catalyzed by glutathione-dependent enzymes. Glutathione usually combines with anticancer drugs and/or their metabolites to form more polar...

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• Drugs and driving

  Publication

  • J. Staniszewski
  • W. Kustra

  - Year 2007

  W referacie przedstawiono we wprowadzeniu pojawienie się nowego zagrożenia, jakim jest kierowanie pojazdów przez osoby będące pod wpływek narkotyków. W drugiej części przedstawiono obecnie obowiązujące sankcje, jakie mogą spotkać kierującego oraz definicję środków odurzających, po zażyciu których nie można prowadzić samochodu. W trzeciej części przedstawiono badania naukowe przeprowadzone w Polsce i Niemczech, które pokazują jak...

• Piperine Targets Different Drug Resistance Mechanisms in Human Ovarian Cancer Cell Lines Leading to Increased Sensitivity to Cytotoxic Drugs

  Publication

  • K. Wojtowicz
  • K. Sterzyńska
  • M. Świerczewska
  • M. Nowicki
  • M. Zabel
  • R. Januchowski

  - International Journal of Molecular Sciences - Year 2021

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• Antipsychotic drug prescription sequence analysis in relation to death occurrence and cardiometabolic drug usage: A retrospective longitudinal study

  Publication

  • P. Zagozdzon
  • P. Dorozynski
  • P. Waszak
  • A. Harasimowicz
  • T. Dziubich

  - EUROPEAN JOURNAL OF PSYCHIATRY - Year 2023

  The potential role of antipsychotics in increasing cardiovascular risk of mortality is still debated. The aim of this study was to assess the death risk associated with sequences of first-generation antipsychotic (FGA) and second-generation antipsychotic (SGA) prescriptions, including clozapine and lithium, and drugs for cardiometabolic diseases. We conducted a retrospective longitudinal analysis involving 84,881 patients who received...

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• DRUGS

  Journals

  ISSN: 0012-6667 , eISSN: 1179-1950

• International Journal for Parasitology-Drugs and Drug Resistance

  Journals

  ISSN: 2211-3207

• Polyurethanes as a carrier of drugs for gentamicin

  Publication

  • A. Rutkowska
  • I. Gibas
  • G. Gorczyca

  - Year 2011

  Gentamicin is one of the most popular drug and is widely used due to its antibiotic properties. 3% of world production of polyurethanes (PU) is dedicated to biomedical applications, where they can serve are parts of orthopedic prosthesis or artificial organs, disposable medical devices, wound and burn dressing, contact lenses among others. In the study, to obtain drug carriers, a combination of these two materials were prepared...