Search results for: RADIOSENSITISATION

• Radiosensitization of DNA in presence of Pt(II)-based compounds

  Publication

  • M. Śmiałek-Telega
  • S. Ptasińska
  • J. Gow
  • C. Da Pieve
  • N. J. Mason

  - EUROPEAN PHYSICAL JOURNAL D - Year 2014

  X-ray irradiation of plasmid DNA in presence of platinum (II)-based compounds was carried out in order to assess the radiosensitization capabilities of these drugs. In present investigations pBR322 plasmid DNA was used to monitor the effectiveness of chosen compounds in inducing strand breaks. Samples were incubated in the presence of potential radiosensitisers: platinum (II) bromide and cis-diamminedibromoplatinum (II). The results...

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• Gold nanoparticles for cancer radiotherapy: a review

  Publication

  • K. Haume
  • S. Rosa
  • S. Grellet
  • M. Śmiałek-Telega
  • K. Butterworth
  • A. V. Solov’yov
  • K. Prise
  • J. Golding
  • N. J. Mason

  - Cancer Nanotechnology - Year 2016

  Radiotherapy is currently used in around 50% of cancer treatments and relies on the deposition of energy directly into tumour tissue. Although it is generally effective, some of the deposited energy can adversely affect healthy tissue outside the tumour volume, especially in the case of photon radiation (gamma and X-rays). Improved radiotherapy outcomes can be achieved by employing ion beams due to the characteristic energy deposition...

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