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Abstract
X-ray irradiation of plasmid DNA in presence of platinum (II)-based compounds was carried out in order to assess the radiosensitization capabilities of these drugs. In present investigations pBR322 plasmid DNA was used to monitor the effectiveness of chosen compounds in inducing strand breaks. Samples were incubated in the presence of potential radiosensitisers: platinum (II) bromide and cis-diamminedibromoplatinum (II). The results were examined against a common cancer chemotherapy drug cis-diamminedichloroplatinum (II). It was found that platinum (II) bromide can greatly increase the levels of single- and double-strand break formation observed in the irradiated samples with respect to the samples containing platinum as a radiosensitizer only, possessing very little chemotherapeutic activity. The suggested drugs exhibit much higher level of radiosensitivity than widely used cisplatin and thus may be good candidates for cancer treatment.
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Authors (5)
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Sylwia Ptasińska
- Radiation Laboratory and Department of Physics University of Notre Dame
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Jason Gow
- The Open University Department of Physical Sciences
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Chiara Da Pieve
- The Open University Department of Life, Health and Chemical Sciences
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Nigel J. Mason
- The Open University Department of Physical Sciences
Cite as
Full text
- Publication version
- Accepted or Published Version
- DOI:
- Digital Object Identifier (open in new tab) 10.1140/epjd/e2014-40846-7
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Details
- Category:
- Articles
- Type:
- artykuł w czasopiśmie wyróżnionym w JCR
- Published in:
-
EUROPEAN PHYSICAL JOURNAL D
no. 68,
pages 1 - 5,
ISSN: 1434-6060 - Language:
- English
- Publication year:
- 2014
- Bibliographic description:
- Śmiałek-Telega M., Ptasińska S., Gow J., Da Pieve ., Mason N.: Radiosensitization of DNA in presence of Pt(II)-based compounds// EUROPEAN PHYSICAL JOURNAL D. -Vol. 68, nr. 85 (2014), s.1-5
- DOI:
- Digital Object Identifier (open in new tab) 10.1140/epjd/e2014-40846-7
- Verified by:
- Gdańsk University of Technology
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