Radio- and photosensitization of DNA with compounds containing platinum and bromine atoms

Małgorzata Śmiałek-Telega; Sylwia Ptasińska; Jason Gow; Søren Hoffmann; Nigel J. Mason

doi:10.1140/epjd/e2015-60036-5

Radio- and photosensitization of DNA with compounds containing platinum and bromine atoms

Abstract

. Irradiations of plasmid DNA by both X-rays and UV light in the presence and absence of compounds containing platinum and bromine atoms were performed in order to asses the sensitization potential of these compounds. Plasmid DNA pBR322 was incubated with platinum (II) bromide, hydrogen hexabromoplatinate (IV), hydrogen hexahydroxyplatinate (IV) and sodium hexahydroxyplatinate (IV). Incubation was followed by X-ray or UV irradiations. It was found that amongst the sensitizers tested, during irradiations carried out in the presence of platinum (II) bromide, the highest levels of double strand breaks formation upon X-ray treatment were recorded. In contrast much less damage was induced by UV light. Data presented here suggests that this compound may be a promising radiosensitizer for cancer treatment.

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Authors (5)

Małgorzata Śmiałek-Telega dr hab. inż.
Sylwia Ptasińska
- University of Notre Dame Radiation Laboratory and Department of Physics,
Jason Gow
- The Open University Department of Physical Sciences
Søren Hoffmann
- Aarhus University ISA, Department of Physics and Astronomy
Nigel J. Mason
- The Open University Department of Physical Sciences

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DOI:: Digital Object Identifier (open in new tab) 10.1140/epjd/e2015-60036-5
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Category:: Articles
Type:: artykuł w czasopiśmie wyróżnionym w JCR
Published in:: EUROPEAN PHYSICAL JOURNAL D no. 69, edition 121, pages 1 - 6,
ISSN: 1434-6060
Language:: English
Publication year:: 2015
Bibliographic description:: Śmiałek-Telega M., Ptasińska S., Gow J., Hoffmann S., Mason N.: Radio- and photosensitization of DNA with compounds containing platinum and bromine atoms// EUROPEAN PHYSICAL JOURNAL D. -Vol. 69, iss. 121 (2015), s.1-6
DOI:: Digital Object Identifier (open in new tab) 10.1140/epjd/e2015-60036-5
Verified by:: Gdańsk University of Technology