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Ipertrofan Revisited—The Proposal of the Complete Stereochemistry of Mepartricin A and B
Publication
- P. Szczeblewski
- W. Andrałojć
- J. Polit
- A. Żabka
- K. Winnicki
- T. Laskowski
- MOLECULES - Year 2021
Being a methyl ester of partricin, the mepartricin complex is the active substance of a drug called Ipertrofan (Tricandil), which was proven to be useful in treatment of benign prostatic hyperplasia and chronic nonbacterial prostatitis/chronic pelvic pain syndrome. Nevertheless, no direct structural evidence on the stereochemistry of its components has been presented to date. In this contribution, we have conducted detailed, NMR-driven...

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