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Search results for: PLESSNER
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Lipidation of Temporin-1CEb Derivatives as a Tool for Activity Improvement, Pros and Cons of the Approach
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DNA-reactive anticancer imidazoacridinone C-1311 is a new inhibitor of hypoxia-inducible factor 1 alpha, vascular endothelial growth factor and tumor angiogenesis
PublicationHypoxia-inducible factor 1 (HIF-1) plays a critical role for tumor adaptation to hypoxia and promotes angiogenesis. Antitumor imidazoacridinone C-1311 is a DNA reactive topoisomerase II and FLT3 receptor tyrosine kinase inhibitor selected for phase II clinical trials for breast cancer. Here, we demonstrate the new mechanism of C-1311 action involving HIF-1a, vascular endothelial growth factor (VEGF) and angiogenesis as additional...
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One Step Beyond: Design of Substrates Spanning Primed Positions of Zika Virus NS2B-NS3 Protease
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Bile Acids: Key Players in Inflammatory Bowel Diseases?
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SP-1, a Serine Protease from the Gut Microbiota, Influences Colitis and Drives Intestinal Dysbiosis in Mice
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Structural and Functional Analysis of Human HtrA3 Protease and Its Subdomains
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Gut Serpinome: Emerging Evidence in IBD
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Design and synthesis of new substrates of HtrA2 protease
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PEGylated substrates of NSP4 protease: A tool to study protease specificity
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Trypsin inhibitors from the garden four o’clock (Mirabilis jalapa) and spinach (Spinacia oleracea) seeds: Isolation, characterization and chemical synthesis
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Properties of the HtrA Protease From Bacterium Helicobacter pylori Whose Activity Is Indispensable for Growth Under Stress Conditions
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Cathepsin C is a novel mediator of podocyte and renal injury induced by hyperglycemia
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Intra- and intersubunit changes accompanying thermal activation of the HtrA2(Omi) protease homotrimer
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Fecal Serine Protease Profiling in Inflammatory Bowel Diseases
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The LA Loop as an Important Regulatory Element of the HtrA (DegP) Protease from Escherichia coli
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Temperature-induced changes of HtrA2(Omi) protease activity and structure
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Processing and Maturation of Cathepsin C Zymogen: A Biochemical and Molecular Modeling Analysis
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Lactoferrin Is an Allosteric Enhancer of the Proteolytic Activity of Cathepsin G
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Biochemical properties of the HtrA homolog from bacterium Stenotrophomonas maltophilia
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Synthesis of Novel Phosphonic‐Type Activity‐Based Probes for Neutrophil Serine Proteases and Their Application in Spleen Lysates of Different Organisms
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Structural Determinants of Substrate Specificity of SplF Protease from Staphylococcus aureus
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Neutrophil proteinase 3 and dipeptidyl peptidase I (cathepsin C) as pharmacological targets in granulomatosis with polyangiitis (Wegener granulomatosis)
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Kallikrein 13 serves as a priming protease during infection by the human coronavirus HKU1
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Proteinase release from activated neutrophils in mechanically ventilated patients with non-COVID-19 and COVID-19 pneumonia
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A Novel Biological Role for Peptidyl-Arginine Deiminases: Citrullination of Cathelicidin LL-37 Controls the Immunostimulatory Potential of Cell-Free DNA
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Selection of Effective HTRA3 Activators Using Combinatorial Chemistry
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Human proteinase 3 resistance to inhibition extends to alpha‐2 macroglobulin
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Analysis of the Link between the Redox State and Enzymatic Activity of the HtrA (DegP) Protein from Escherichia coli
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Bias-Dependent Dynamics of Degradation and Recovery in Perovskite Solar Cells
PublicationDegradation of perovskite solar cells (PSCs) is often found to be partially or fully reversible when the cells are allowed to recover in the dark. Unlike the dynamics of degradation, knowledge about the dynamics of PSC cell recovery is very limited. Here, we demonstrate that the PSC recovery strongly depends on the electrical bias conditions during the light-induced degradation and that it can be manipulated by applying an external...
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Cathepsin G activity lowers plasma LDL and reduces atherosclerosis
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Exploiting the S4–S5 Specificity of Human Neutrophil Proteinase 3 to Improve the Potency of Peptidyl Di(chlorophenyl)-phosphonate Ester Inhibitors: A Kinetic and Molecular Modeling Analysis
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New Selective Peptidyl Di(chlorophenyl) Phosphonate Esters for Visualizing and Blocking Neutrophil Proteinase 3 in Human Diseases
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Substrate specificity of Staphylococcus aureus cysteine proteases – Staphopains A, B and C
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Neutrophilic Cathepsin C Is Maturated by a Multistep Proteolytic Process and Secreted by Activated Cells during Inflammatory Lung Diseases
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The molecular function of kallikrein‐related peptidase 14 demonstrates a key modulatory role in advanced prostate cancer
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Biochemical and Structural Characterization of SplD Protease from Staphylococcus aureus
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Chapter 13. Immunological determination of the pharmaceutical diclofenac in environmental and biological samples
PublicationOpracowano wysoce specyficzną i czułą metodę immunologiczną oznaczania przeciwzapalnego leku diklofenaku. Jest to jeden z najczęściej wykrywanych farmaceutyków w środowisku. Granicę wykrywalności oraz wartość IC50 określono na poziomie 6 ng/L oraz 60 ng/L dla wody wodociągowej, odpowiednio. W badaniu porównawczym, stosując test ELISA oraz GC-MS określono poziomy stężeń diklofenaku w wodach ściekowych z 21 oczyszczalni ścieków i...
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Aggregated neutrophil extracellular traps resolve inflammation by proteolysis of cytokines and chemokines and protection from antiproteases
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Development of Chemical Tools to Monitor Human Kallikrein 13 (KLK13) Activity
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Therapeutic targeting of cathepsin C: from pathophysiology to treatment
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Prolonged pharmacological inhibition of cathepsin C results in elimination of neutrophil serine proteases
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Design and implementation of an illumination system to mimic skyglow at ecosystem level in a large‐scale lake enclosure facility
PublicationLight pollution is an environmental stressor of global extent that is growing exponentially in area and intensity. Artificial skyglow, a form of light pollution with large range, is hypothesized to have environmental impact at ecosystem level. However, testing the impact of skyglow at large scales and in a controlled fashion under in situ conditions has remained elusive so far. Here we present the first experimental setup to mimic...
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Kallikrein-related peptidase 14 activates zymogens of membrane type matrix metalloproteinases (MT-MMPs) - a CleavEx library-based analysis
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Kallikrein-Related Peptidase 14 Activates Zymogens of Membrane Type Matrix Metalloproteinases (MT-MMPs)—A CleavEx Based Analysis
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Consequences of cathepsin C inactivation for membrane exposure of proteinase 3, the target antigen in autoimmune vasculitis
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Myeloperoxidase Modulates Inflammation in Generalized Pustular Psoriasis and Additional Rare Pustular Skin Diseases
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Analysis of urinary cathepsin C for diagnosing Papillon–Lefèvre syndrome
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18th European Symposium on Radiopharmacy and Radiopharmaceuticals
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Surgeons’ practice and preferences for the anal fissure treatment: results from an international survey
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Elective surgery system strengthening: development, measurement, and validation of the surgical preparedness index across 1632 hospitals in 119 countries
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