Search results for: HETEROPLAZMIA

• Naturally occurring mitochondrial DNA heteroplasmy in the MRL mouse

  Publication

  • P. Sachadyn
  • X. Zhang
  • L. D. Clark
  • R. K. Naviaux
  • E. Heber-Katz

  - MITOCHONDRION - Year 2008

  The MRL/MpJ mouse is an inbred laboratory strain of Mus musculus, known to exhibit enhanced autoimmunity, increased wound healing, and increased regeneration properties. We report the full-length mitochondrial DNA (mtDNA) sequence of the MRL mouse (Accession # EU450583), and characterize the discovery of two naturally occurring heteroplasmic sites. The first is a T3900C substitution in the TpsiCloop of the tRNA methionine gene...

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• Molecular differences in mitochondrial DNA (mtDNA) genomes of dogs with malignant mammary tumours

  Open Research Data

  open access

  • B. Ślaska
  • K. Kowal
  • A. Tkaczyk-Wlizło
  • M. Pierzchała
  • J. Gawor

  The aim of this study was to determine molecular defects in mitochondrial DNA with the use of large-scale genome analysis in malignant canine mammary gland tumours and indicate whether these changes were linked with the carcinogenesis process. With the use of the NGS technology, we sequenced 27 samples of mtDNA isolated from blood and tumours obtained...