Search results for: OXYSTEROLS

• Dabigatran: its protective effect against endothelial cell damage by oxysterol

  Publication

  • P. Gorzelak-Pabiś
  • M. Broncel
  • A. Pawlos
  • K. Wojdan
  • A. Gajewski
  • M. Chałubiński
  • E. Woźniak

  - BIOMEDICINE & PHARMACOTHERAPY - Year 2022

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• Rivaroxaban protects from the oxysterol-induced damage and inflammatory activation of the vascular endothelium

  Publication

  • P. Gorzelak-Pabis
  • M. Broncel
  • K. Wojdan
  • A. Gajewski
  • M. Chalubinski
  • M. Gawrysiak
  • E. Wozniak

  - Tissue Barriers - Year 2021

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• Accelerated remyelination and immune modulation by the EBI2 agonist 7α,25-dihydroxycholesterol analogue in the cuprizone model

  Publication

  • K. Konieczna-Wolska
  • F. Caratis
  • M. Opiełka
  • K. Biernacki
  • K. Urbanowicz
  • J. Klimaszewska
  • P. Pobiarzyn
  • O. Krajewski
  • S. Demkowicz
  • R. T. Smoleński... and 3 others

  - BIOMEDICINE & PHARMACOTHERAPY - Year 2024

  Research indicates a role for EBI2 receptor in remyelination, demonstrating that its deficiency or antagonism inhibits this process. However, activation of EBI2 with its endogenous ligand, oxysterol 7α,25-dihydroxycholesterol (7α,25OHC), does not enhance remyelination beyond the levels observed in spontaneously remyelinating tissue. We hypothesized that the short half-life of the natural ligand might explain this lack of beneficial...

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