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Search results for: tumor microenvironment
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Loss of DRO1/CCDC80 in the tumor microenvironment promotes carcinogenesis
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Cancer Microenvironment
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Tumor
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TUMOR BIOLOGY
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Identification of High-Risk Stage II Colorectal Tumors by Combined Analysis of the NDRG1 Gene Expression and the Depth of Tumor Invasion
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Enhanced Suppressive Activity of Regulatory T Cells in the Microenvironment of Malignant Pleural Effusions
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Determination of bisphenol A in size fractions of indoor dust from several microenvironments
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Lipoic Acid-Coated Silver Nanoparticles: Biosafety Potential on the Vascular Microenvironment and Antibacterial Properties
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Anti-Tumor Pharmacy
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Progress in tumor research
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Recent advances in 3D bioprinted tumor models for personalized medicine
PublicationCancerous tumors are among the most fatal diseases worldwide, claiming nearly 10 million lives in 2020. Due to their complex and dynamic nature, modeling tumors accurately is a challenging task. Current models suffer from inadequate translation between in vitro and in vivo results, primarily due to the isotropic nature of tumors and their microenvironment's relationship. To address these limitations, hydrogel-based 3D bioprinting...
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HUMOR: International Journal of Humor Research
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Gastrointestinal Tumors
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Rare Tumors
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The potential anti-tumor activity of neoteric solvents
PublicationCiecze jonowe stały się obiektem zainteresowania naukowców. Znajdują one coraz to szersze zastosowanie. Dlatego też ważne jest określenie ich właściwości Eko-toksycznych. Aktywność anty-nowotworowa i cytotoksyczna cieczy jonowych stała się zatem ważnym aspektem badań. Artykuł podsumowuje najnowsze wyniki badań nad cytotoksycznością tych rozpuszczalników
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Tumor Diagnostik und Therapie
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PROGRESS IN EXPERIMENTAL TUMOR RESEARCH
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Image Segmentation of MRI image for Brain Tumor Detection
Publicationthis research work presents a new technique for brain tumor detection by the combination of Watershed algorithm with Fuzzy K-means and Fuzzy C-means (KIFCM) clustering. The MATLAB based proposed simulation model is used to improve the computational simplicity, noise sensitivities, and accuracy rate of segmentation, detection and extraction from MR...
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Gemcitabine Peptide-Based Conjugates and Their Application in Targeted Tumor Therapy
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Clinical Relevance of Circulating Tumor Cells in Prostate Cancer Management
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Current Challenges in Targeting Tumor Desmoplasia to Improve the Efficacy of Immunotherapy
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Holistic Approach to the Diagnosis and Treatment of Patients with Tumor Metastases to the Spine
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Journal of Solid Tumors
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Studies in American Humor
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Tumour Virus Research
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Cadmium, arsenic, selenium and iron– Implications for tumor progression in breast cancer
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Progress in targeting tumor cells by using drug-magnetic nanoparticles conjugate.
PublicationTo limit the cytotoxicity of anticancer drugs against healthy cells, an appropriate carrier should be synthesized to deliver the drug to the tumor tissue only. A good solution is to anchor a magnetic nanoparticle to the molecule of the drug and to use a properly directed external magnetic field. We have shown that the improved by us synthesis of the conjugate of doxorubicin with iron-oxide magnetic nanoparticles allows a substantial...
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Naturally-derived hydrogels for 3D pancreatic tumor models: A short review
PublicationStatistics suggest a high proportion of mortality rate by pancreatic cancer, which is a solid tumor characterized by high heterogeneity and the presence of a complex extracellular matrix. The very low effectiveness of pancreatic cancer treatment roots in the high metastatic potential and drug resistance of this tumor. Therefore, the quest for efficient cellular models enabling precise mimicking in vivo conditions, and anticancer...
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ColorNephroNet: Kidney tumor malignancy prediction using medical image colorization
PublicationRenal tumor malignancy classification is one of the crucial tasks in urology, being a primary factor included in the decision of whether to perform kidney removal surgery (nephrectomy) or not. Currently, tumor malignancy prediction is determined by the radiological diagnosis based on computed tomography (CT) images. However, it is estimated that up to 16% of nephrectomies could have been avoided because the tumor that had been...
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Stromal expression of ALDH1 in human breast carcinomas indicates reduced tumor progression
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Regarding the concurrent presence of secretory carcinoma and Warthin’s tumor in the ipsilateral parotid gland
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Overcome the tumor immunotherapy resistance by combination of the HDAC6 inhibitors with antitumor Immunomodulatory agents.
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Total DNA methylation as a biomarker of DNA damage and tumor malignancy in intracranial meningiomas
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Comparison of Selected Neural Network Models Used for Automatic Liver Tumor Segmentation
PublicationAutomatic and accurate segmentation of liver tumors is crucial for the diagnosis and treatment of hepatocellular carcinoma or metastases. However, the task remains challenging due to imprecise boundaries and significant variations in the shape, size, and location of tumors. The present study focuses on tumor segmentation as a more critical aspect from a medical perspective, compared to liver parenchyma segmentation, which is the...
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Comparison of the ability to induce apoptosis by acridine derivatives in solid tumor and leukemia cells
PublicationW pracy wykazano różną wrażliwość komórek nowotworowych do ulegania apoptozie pod wpływem pochodnych akrydyny.
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Detection of circulating tumor cells by means of machine learning using Smart-Seq2 sequencing
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MiMSeg - an algorithm for automated detection of tumor tissue on NMR apparent diffusion coefficient maps.
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Metabolomic approach for determination of urinary nucleosides as potential tumor markers using electromigration techniques
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Carbon nanotube based dielectric spectroscopy of tumor secretion; electrochemical lipidomics for cancer diagnosis
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Coordinated reprogramming of renal cancer transcriptome, metabolome and secretome associates with immune tumor infiltration
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Expression of pendrin and NIS iodide transporters in human breast tumor and peri-tumoral tissue
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Strategies for overcoming ABC-transporters-mediated multidrug resistance (MDR) of tumor cells. Review
PublicationOporność wielolekowa (MDR) nowotworów jest główną przyczyną niepowodzeń w chemoterapii przeciwnowotworowej. Jest ona wynikiem nadprodukcji w komórkach opornych transporterów białkowych z nadrodziny ABC, eksportujących cytostatyk z komórki, których działanie uniemożliwia utrzymanie terapeutycznego stężenia leku. W publikacji dokonano przeglądu różnych strategii przeciwdziałania zjawisku MDR. Strategie te dotyczą zarówno kontroli...
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Interstrand crosslinking of DNA in tumor and fibroblast cells by C-1311 (Symadex) and other imidazoacridinones
PublicationImidazoakrydony, w tym pochodna C-1311 znajdująca się w pierwszej fazie badań klinicznych prowadzonych przez firmę Xanthus Life Sciences, należą do grupy bardzo aktywnych związków przeciwnowotworowych zsyntetyzowanych w Katedrze Technologii Leków i Biochemii PG. Za pomocą zmodyfikowanej metody Parsons'a wykazaliśmy, że C-1311 indukuje w sposób zależny od stężenia międzyłańcuchowe wiązania sieciujące w komórkach różnych nowotworów...
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Detection of circulating tumor cells by means of machine learning using Smart-Seq2 sequencing
PublicationCirculating tumor cells (CTCs) are tumor cells that separate from the solid tumor and enter the bloodstream, which can cause metastasis. Detection and enumeration of CTCs show promising potential as a predictor for prognosis in cancer patients. Furthermore, single-cells sequencing is a technique that provides genetic information from individual cells and allows to classify them precisely and reliably. Sequencing data typically...
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Enhancing Renal Tumor Detection: Leveraging Artificial Neural Networks in Computed Tomography Analysis
PublicationRenal cell carcinoma is one of the most common cancers in Europe, with a total incidence rate of 18.4 cases per 100 000 population. There is currently significant overdiagnosis (11% to 30.9%) at times of planned surgery based on radiological studies. The purpose of this study was to create an artificial neural network (ANN) solution based on computed tomography (CT) images as an additional tool to improve the differentiation of...
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Evaluation of survivin splice variants in pituitary tumors
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The Stability of 4‐Chloromethcathinone in Blood and Vitreous Humor
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Cytokine IL6, but not IL-1β, TNF-α and NF-κB is increased in paediatric cancer patients
PublicationCytokines are responsible for maintaining homeostasis as cell growth, differentiation, migration and apoptosis mediators. They play a pivotal role in immune responses to inflammatory reactions. In oncological diseases, the cross-talk between cells of the immunological system and cells of the tumour microenvironment is led by cytokines. Also, the overproduction of cytokines may change the tumour microenvironment and stimulate tumour...
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Thalia: Studies in Literary Humor
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The Degree of Global DNA Hypomethylation in Peripheral Blood Correlates with That in Matched Tumor Tissues in Several Neoplasia
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