Tomasz Chmielewski - Publications - Bridge of Knowledge

Tomasz Chmielewski

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lyme disease, borrelia burgdorferi sensu lato, epitope mapping, serodiagnosis, chimeric proteins

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Year 2023

Epitope Mapping of BmpA and BBK32 Borrelia burgdorferi Sensu Stricto Antigens for the Design of Chimeric Proteins with Potential Diagnostic Value
Publication
- W. Grąźlewska
- L. Holec-Gąsior
- K. Sołowińska
- T. Chmielewski
- B. Fiecek
- M. Contreras Rojo
- ACS Infectious Diseases - Year 2023
Lyme disease is a tick-borne zoonosis caused by Gramnegative bacteria belonging to the Borrelia burgdorferi sensu lato (s.l.) group. In this study, IgM- and IgG-specific linear epitopes of two B. burgdorferi sensu stricto (s.s.) antigens BmpA and BBK32 were mapped using a polypeptide array. Subsequently, two chimeric proteins BmpABBK32-M and BmpA-BBK32-G were designed to validate the construction of chimeras using the identified...

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