Year 2024

• Long-range, water-mediated interaction between a moderately active antifreeze protein molecule and the surface of ice

  Publication

  • J. Grabowska
  • A. Kuffel
  • J. Zielkiewicz

  - JOURNAL OF CHEMICAL PHYSICS - Year 2024

  Using molecular dynamics simulations, we show that a molecule of moderately active antifreeze protein (type III AFP, QAE HPLC-12 isoform) is able to interact with ice in an indirect manner. This interaction occurs between the ice binding site (IBS) of the AFP III molecule and the surface of ice, and it is mediated by liquid water which separates these surfaces. As a result, the AFP III molecule positions itself at a specific orientation...

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Year 2023

• Beyond Antioxidant Activity: Redox Properties of Catechins May Affect Changes in the DNA Methylation Profile—The Example of SRXN1 Gene

  Publication

  • P. Jakubek
  • R. Jovana
  • M. Baranowska
  • K. Suliborska
  • M. Heldt
  • K. Dziedziul
  • M. Vidaković
  • J. Namieśnik
  • A. Bartoszek-Pączkowska

  - Antioxidants - Year 2023

  The role of catechins in the epigenetic regulation of gene expression has been widely studied; however, if and how this phenomenon relates to the redox properties of these polyphenols remains unknown. Our earlier study demonstrated that exposure of the human colon adenocarcinoma HT29 cell line to these antioxidants affects the expression of redox-related genes. In particular, treatment with (−)-epigallocatechin (EGC) downregulated...

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