Rok 2012

• Diminshed toxicity of C-1748, 4-methyl-9-hydroxyethylamino-1-nitroacridine, compared with its demethyl analog, C-857, corresponds to its resistance to metabolism in HepG2 cells

  Publikacja

  • A. Wiśniewska
  • M. Niemira
  • K. Jagiełło
  • A. Potęga
  • M. Świst
  • C. Henderson
  • A. Skwarska
  • E. Augustin
  • J. Konopa
  • Z. Mazerska

  - BIOCHEMICAL PHARMACOLOGY - Rok 2012

  The narrow "therapeutic window" of anti-tumour therapy may be the result of drug metabolism leading to the activation or detoxification of antitumour agents. The aim of this work is to examine (i) whether the diminished toxicity of a potent antitumour drug, C-1748, 9-(2'-hydroxyethylamino)-4-methyl-1-nitroacridine, compared with its 4-demethyl analogue, C-857, results from the differences between the metabolic pathways for the...

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