![Zdjęcie profilowe: Michał Beffinger](/assets/michal-beffinger,59581-1/photo.png)
Michał Beffinger
Zatrudnienie
Publikacje
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wszystkich: 2
Katalog Publikacji
Rok 2015
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Targeting of FLT3-ITD kinase contributes to high selectivity of imidazoacridinone C-1311 against FLT3-activated leukemia cells
PublikacjaDrugs targeting receptor tyrosine kinase FLT3 are of particular interest since activating FLT3-internal tandem duplication (ITD) mutations abundantly occur in fatal acute myeloid leukemias (AMLs). Imidazoacridinone C-1311, a DNA-reactive inhibitor of topoisomerase II, has been previously shown to be a potent and selective inhibitor of recombinant FLT3. Here, we expand those findings by studying its effect on leukemia cells with...
Rok 2012
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The Role of FLT3 Kinase as an AML Therapy Target
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