Anticancer and antimicrobial properties of novel η6-p-cymene ruthenium(ii) complexes containing a N,S-type ligand, their structural and theoretical characterization - Publikacja - MOST Wiedzy

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Anticancer and antimicrobial properties of novel η6-p-cymene ruthenium(ii) complexes containing a N,S-type ligand, their structural and theoretical characterization

Abstrakt

Ruthenium(II) complexes are lately of great scientific interest due to their chemotherapeutic potential asanticancer and antimicrobial agents. Here we present the synthesis of new pyrazole carbothioamidederivatives and their four arene–ruthenium complexes. The title compounds were characterized with theapplication of IR, NMR, mass spectrometry, elemental analysis and X-ray diffraction. Additionally, for newcomplexes DFT calculations were done. Their antimicrobial activity (MIC, MBC/MFC) was examinedinvitroagainstStaphylococcus aureus,Staphylococcus epidermidis,Enterococcus faecalis,Pseudomonasaeruginosa,Proteus vulgarisandCandida albicans. Their cytotoxic effects, using the MTT assay, againstthree cancer cell lines: HL-60, NALM-6, WM-115 and normal human foreskinfibroblasts (HFF-1) werealso investigated. The influence of the new arene–ruthenium(II) complexes on the DNA structure wasalso tested. From our results, compound2dshowed higher cytotoxicity against melanoma cell line WM-115 than cisplatin. Strong biostatic and biocidal activity of the tested complexes against Gram-positivebacteria, includingS. aureus,S. epidermidisandE. faecaliswas demonstrated. The new arene–ruthenium(II) compounds could not only inhibit proliferation of cancer cells, but also protect patientsagainst malignant wound infections.

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Kategoria:
Publikacja w czasopiśmie
Typ:
artykuły w czasopismach
Opublikowano w:
RSC Advances nr 9, strony 38629 - 38645,
ISSN: 2046-2069
Język:
angielski
Rok wydania:
2019
Opis bibliograficzny:
Namiecińska E., Sadowska B., Więckowska-Szakiel M., Dołęga A., Pasternak B., Grazul M., Budzisz E.: Anticancer and antimicrobial properties of novel η6-p-cymene ruthenium(ii) complexes containing a N,S-type ligand, their structural and theoretical characterization// RSC Advances -Vol. 9,iss. 66 (2019), s.38629-38645
DOI:
Cyfrowy identyfikator dokumentu elektronicznego (otwiera się w nowej karcie) 10.1039/c9ra08736b
Weryfikacja:
Politechnika Gdańska

wyświetlono 168 razy

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