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Aptamer based tools for environmental and therapeutic monitoring: A review of developments, applications, future perspectives
Abstrakt
Nucleic acids in the form of aptamers play a growing and significant role in the targeted and rapid analysis of environmental sample composition and medical analyses. In this paper, the review of both aptamers synthesis methods as well as application of these short chain oligonucleotides (with critical comments on their strong and weak features) are given. The first ones include: systematic evolution of ligands by exponential enrichment (SELEX), high throughput aptamer identification screen (HAPIscreen), and a non-equilibrium capillary electrophoresis of equilibrium mixture (NECEEM). Afterwards, manuscript describes variety of sensors and biotests utilizing aptamers as active part of its action starting from electrochemical aptasensors, through optical to piezo-electric ones. Described biotests present basic developments in enzymelinked apta-sorbent assays (ELASA) that can be performed with different variations (enzyme-linked aptamer assay (ELAA), enzyme-linked oligonucleotide assay (ELONA) and aptamerlinked immobilized sorbent assay (ALISA)). Next, the review presents advantages and drawbacks of recent aptameric developments in versatile laboratory applications, namely medical ones, as well as analytical and bioassays. Utilitarian development of aptasensors and aptamers would strongly benefit from an assembly of interdisciplinary teams containing chemists, physicists, biologists, medical doctors, and material and electronic scientists, to determine the most effective application methodologies.
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- Wersja publikacji
- Accepted albo Published Version
- Licencja
- Copyright (2019 Taylor & Francis Group, LLC)
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Informacje szczegółowe
- Kategoria:
- Publikacja w czasopiśmie
- Typ:
- artykuły w czasopismach
- Opublikowano w:
-
CRITICAL REVIEWS IN ENVIRONMENTAL SCIENCE AND TECHNOLOGY
nr 50,
strony 816 - 867,
ISSN: 1064-3389 - Język:
- angielski
- Rok wydania:
- 2020
- Opis bibliograficzny:
- Kudłak B., Wieczerzak M.: Aptamer based tools for environmental and therapeutic monitoring: A review of developments, applications, future perspectives// CRITICAL REVIEWS IN ENVIRONMENTAL SCIENCE AND TECHNOLOGY -Vol. 50,iss. 8 (2020), s.816-867
- DOI:
- Cyfrowy identyfikator dokumentu elektronicznego (otwiera się w nowej karcie) 10.1080/10643389.2019.1634457
- Źródła finansowania:
-
- projekt Miniatura nr 2017/01/X/ST4/00474
- Weryfikacja:
- Politechnika Gdańska
wyświetlono 372 razy
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