Genotoxicity of selected pharmaceuticals, their binary mixtures, and varying environmental conditions – study with human adenocarcinoma cancer HT29 cell line - Publikacja - MOST Wiedzy

Twoje konto

zaloguj

Wyszukiwarka

Genotoxicity of selected pharmaceuticals, their binary mixtures, and varying environmental conditions – study with human adenocarcinoma cancer HT29 cell line

Abstrakt

Pharmaceutical residues are present in the environment in mixtures and their adverse effects may also result from interactions that occur between compounds. Studies presented in this work focus on genotoxicity of pharmaceuticals from different therapeutic groups in mixtures and in individual solutions impacted with different environmental conditions assessed using comet assay (alkaline approach). Binary mixtures of pharmaceuticals (in different concentration ratios) and in individual solutions impacted with pH change (range from 5.5 to 8.5) or addition of inorganic ions, were incubated with HT29 cells and after 24 h time period cells were tested for the presence of DNA damage. To estimate whether mixtures act more (synergistic) or less (antagonistic) efficiently Concentrations Addition (CA) and Independent Action (IA) approaches were applied followed by a calculation of the Model Deviation Ratio (MDR) to determine deviation from the predicted values. Addition of inorganic ions mainly reduced their genotoxicity. Diclofenac s. was the most susceptible to potassium, fluoride, and bromide ions. Change of the pH of pharmaceutical solutions had significant impact on genotoxicity of diclofenac s. and fluoxetine h. Among mixtures, more commonly observed interactions were synergistic ones, exactly twenty-five cases (ten pairs containing chloramphenicol or oxytetracycline h.) and ten cases of antagonism (four for pairs containing chloramphenicol or fluoxetine h.). The results obtained indicate that interactions between tested compounds occur frequently and can lead to DNA damage. This topic especially concerning in vitro tests using cells is still rare, however, it should not be neglected.

Cytowania

  • 5

    CrossRef

  • 0

    Web of Science

  • 5

    Scopus

Autorzy (3)

Cytuj jako

Pełna treść

pobierz publikację
pobrano 210 razy
Wersja publikacji
Accepted albo Published Version
Licencja
Copyright (2018 Informa UK Limited, trading as Taylor & Francis Group)

Słowa kluczowe

Informacje szczegółowe

Kategoria:
Publikacja w czasopiśmie
Typ:
artykuły w czasopismach
Opublikowano w:
DRUG AND CHEMICAL TOXICOLOGY nr 44, strony 113 - 123,
ISSN: 0148-0545
Język:
angielski
Rok wydania:
2019
Opis bibliograficzny:
Wieczerzak M., Namieśnik J., Kudłak B.: Genotoxicity of selected pharmaceuticals, their binary mixtures, and varying environmental conditions – study with human adenocarcinoma cancer HT29 cell line// DRUG AND CHEMICAL TOXICOLOGY -Vol. 44,iss. 2 (2019), s.113-123
DOI:
Cyfrowy identyfikator dokumentu elektronicznego (otwiera się w nowej karcie) 10.1080/01480545.2018.1529783
Bibliografia: test
  1. Avila, C., and Garc ıa, J., 2015. Pharmaceuticals and personal care products (PPCPs) in the environment and their removal from wastewater through constructed wetlands. Comprehensive Analytical Chemistry, 67, 195-244. otwiera się w nowej karcie
  2. Aydin, S., et al., 2017. Antidepressants in urban wastewater treatment plant: occurrence, removal and risk assessment. Global Nest Journal, 19, 100-106. otwiera się w nowej karcie
  3. Backhaus, T., and Faust, M., 2012. Predictive environmental risk assess- ment of chemical mixtures: a conceptual framework. Environmental Science and Technology, 46 (5), 2564-2573. otwiera się w nowej karcie
  4. Barreto, A., et al., 2017. Genotoxicity of gemfibrozil in the gilthead seab- ream (Sparus aurata). Mutation Research/Genetic Toxicology and Environmental Mutagenesis, 821, 36-42. otwiera się w nowej karcie
  5. Belden, J.B., Gilliom, R.J., and Lydy, M.J., 2007. How well can we predict the toxicity of pesticide mixtures to aquatic life? Integrated Environmental Assessment and Management, 3 (3), 364-372. otwiera się w nowej karcie
  6. Blystone, C.R., et al., 2011. Toxicity and carcinogenicity of androstene- dione in F344/N rats and B6C3F1 mice. Food and Chemical Toxicology: an International Journal Published for the British Industrial Biological Research Association, 49 (9), 2116-2124. otwiera się w nowej karcie
  7. Bocchi, C., et al., 2016. Characterization of urban aerosol: seasonal vari- ation of mutagenicity and genotoxicity of PM 2.5, PM 1 and semi- volatile organic compounds. Mutation Research/Genetic Toxicology and Environmental Mutagenesis, 809, 16-23. otwiera się w nowej karcie
  8. Caban, M., et al., 2015. Determination of pharmaceutical residues in drinking water in Poland using a new SPE-GC-MS (SIM) method based on Speedisk extraction disks and DIMETRIS derivatization. Science of the Total Environment, 538, 402-411. otwiera się w nowej karcie
  9. Chae, J.P., et al., 2015. Evaluation of developmental toxicity and terato- genicity of diclofenac using Xenopus embryos. Chemosphere, 120, 52-58. otwiera się w nowej karcie
  10. Charles, E., et al., 2017. The antidepressant fluoxetine induces necrosis by energy depletion and mitochondrial calcium overload. Oncotarget, 8, 3181-3196. otwiera się w nowej karcie
  11. Chen, C., et al., 2015. The synergistic toxicity of the multiple chemical mixtures: implications for risk assessment in the terrestrial environ- ment. Environment International, 77, 95-105. otwiera się w nowej karcie
  12. Cuthbert, R.J., et al., 2016. Continuing mortality of vultures in India asso- ciated with illegal veterinary use of diclofenac and a potential threat from nimesulide. Oryx, 50 (01), 104-112. otwiera się w nowej karcie
  13. Drescher, K., and Boedeker, W., 1995. Assessment of the combined effects of substances: the relationship between concentration addition and independent action. Biometrics, 51 (2), 716-730. otwiera się w nowej karcie
  14. Durgo, K., et al., 2009. The assessment of genotoxic effects of wastewater from a fertilizer factory. Journal of Applied Toxicology, 29 (1), 42-51. otwiera się w nowej karcie
  15. Ebele, A.J., Abdallah, M.A.E., and Harrad, S., 2017. Pharmaceuticals and personal care products (PPCPs) in the freshwater aquatic environment. Emerging Contaminants, 3 (1), 1-16. otwiera się w nowej karcie
  16. Eggen, T., Moeder, M., and Arukwe, A., 2010. Municipal landfill leachates: a significant source for new and emerging pollutants. Environmental Science and Technology, 408 (21), 5147-5157. otwiera się w nowej karcie
  17. Fairbairn, D.W., Olive, P.L., and O'Neill, K.L., 1995. The comet assay: a comprehensive review. Mutation Research/Reviews in Genetic Toxicology, 339 (1), 37-59. otwiera się w nowej karcie
  18. Faust, M., et al., 2000. Predictive assessment of the aquatic toxicity of multiple chemical mixtures. Journal of Environment Quality, 29 (4), 1063-1068., Fent, K., Weston, A.A., and Caminada, D., 2006. Ecotoxicology of human pharmaceuticals. Aquatic Toxicology (Amsterdam, Netherlands), 76 (2), 122-159.
  19. Fu, L., et al., 2017. Toxicity of 13 different antibiotics towards freshwater green algae Pseudokirchneriella subcapitata and their modes of action. Chemosphere, 168, 217-222. otwiera się w nowej karcie
  20. Gaw, S., Thomas, K.V., and Hutchinson, T.H., 2014. Sources, impacts and trends of pharmaceuticals in the marine and coastal environment. Philosophical Transactions of the Royal Society B, 369, 1-11. otwiera się w nowej karcie
  21. Gonz alez-Pleiter, M., et al., 2013. Toxicity of five antibiotics and their mix- tures towards photosynthetic aquatic organisms: implications for environmental risk assessment. Water Research, 47 (6), 2050-2064. otwiera się w nowej karcie
  22. Huang, B., et al., 2014. Chlorinated volatile organic compounds (Cl-VOCs) in environment-sources, potential human health impacts, and cur- rent remediation technologies. Environment International, 71, 118-138. otwiera się w nowej karcie
  23. Huebner, M., et al., 2015. Rapid analysis of diclofenac in freshwater and wastewater by a monoclonal antibody-based highly sensitive ELISA. Analytical and Bioanalytical Chemistry, 407 (29), 8873-8882. otwiera się w nowej karcie
  24. Hurst, N.F., Bibolini, M.J., and Roth, G.A., 2015. Diazepam inhibits prolifer- ation of lymph node cells isolated from rats with experimental auto- immune encephalomyelitis. Neuroimmunomodulation, 22 (5), 293-302.
  25. Kazimirova, A., et al., 2012. Genotoxicity testing of PLGA-PEO nanopar- ticles in TK6 cells by the comet assay and the cytokinesis-block micro- nucleus assay. Mutation Research, 748 (1-2), 42-47. otwiera się w nowej karcie
  26. Kienzler, A., et al., 2016. Regulatory assessment of chemical mixtures: requirements. current approaches and future perspectives. Regulatory Toxicology and Pharmacology, 80, 321-334. otwiera się w nowej karcie
  27. Koss-Mikołajczyk, I., et al., 2015. Juices from non-typical edible fruits as health-promoting acidity regulators for food industry. LWT-Food Science and Technology, 64 (2), 845-852. otwiera się w nowej karcie
  28. Kudłak, B., et al., 2016. Environmental risk assessment of Polish waste- water treatment plant activity. Chemosphere, 160, 181-188. otwiera się w nowej karcie
  29. Lah, B., et al., 2005. Monitoring of genotoxicity in drinking water using in vitro comet assay and Ames test. Food Technology and Biotechnology, 43, 139-146. otwiera się w nowej karcie
  30. Li, W.C., 2014. Occurrence, sources, and fate of pharmaceuticals in aquatic environment and soil. Environmental Pollution (Barking, Essex: 1987), 187, 193-201. otwiera się w nowej karcie
  31. Liu, S., et al., 2015. Steroids in marine aquaculture farms surrounding Hailing Island, South China: occurrence, bioconcentration, and human dietary exposure. Science of the Total Environment, 502, 400-407. otwiera się w nowej karcie
  32. Mihaljevic, Z., et al., 2011. Assessment of genotoxic potency of sulfate- rich surface waters on medicinal leech and human leukocytes using different versions of the Comet assay. Ecotoxicology and Environmental Safety, 74 (5), 1416-1426. otwiera się w nowej karcie
  33. Nasuhoglu, D., Berk, D., and Yargeau, V., 2012. Photocatalytic removal of 17a-ethinylestradiol (EE2) and levonorgestrel (LNG) from contraceptive pill manufacturing plant wastewater under UVC radiation. Chemical Engineering Journal, 185-186, 52-60. otwiera się w nowej karcie
  34. Ogueji, E.O., et al., 2017. Toxicity of diazepam on lipid peroxidation, bio- chemical and oxidative stress indicators on liver and gill tissues of African catfish Clarias gariepinus. International Journal of Fisheries and Aquatic Studies, 5, 114-123. otwiera się w nowej karcie
  35. Olive, P.L., and Ban ath, J.P., 2006. The comet assay: a method to measure DNA damage in individual cells. Nature Protocols, 1 (1), 23. otwiera się w nowej karcie
  36. Orn, S., Holbech, H., and Norrgren, L., 2016. Sexual disruption in zebrafish (Danio rerio) exposed to mixtures of 17a-ethinylestradiol and 17b-tren- bolone. Environmental Toxicology and Pharmacology, 41, 225-231.
  37. Papageorgiou, M., Kosma, C., and Lambropoulou, D., 2016. Seasonal occurrence, removal, mass loading and environmental risk assessment of 55 pharmaceuticals and personal care products in a municipal wastewater treatment plant in Central Greece. Science of the Total Environment, 543, 547-569. otwiera się w nowej karcie
  38. Parasuraman, S., 2011. Toxicological screening. J Pharmacol Pharmacother, 2 (2), 74. otwiera się w nowej karcie
  39. Parolini, M., et al., 2011. Cytotoxicity assessment of four pharmaceutical compounds on the zebra mussel (Dreissena polymorpha) haemocytes, gill and digestive gland primary cell cultures. Chemosphere, 84 (1), 91-100. otwiera się w nowej karcie
  40. Petrie, B., Barden, R., and Kasprzyk-Hordern, B., 2015. A review on emerg- ing contaminants in wastewaters and the environment: current know- ledge, understudied areas and recommendations for future monitoring. Water Research, 72, 3-27. otwiera się w nowej karcie
  41. Pomati, F., et al., 2006. Effects of a complex mixture of therapeutic drugs at environmental levels on human embryonic cells. Environmental Science and Technology, 40 (7), 2442-2447. otwiera się w nowej karcie
  42. Ren, X., et al., 2017. Toxic responses of swimming crab (Portunus trituber- culatus) larvae exposed to environmentally realistic concentrations of oxytetracycline. Chemosphere, 173, 563-571. otwiera się w nowej karcie
  43. Sui, Q., et al., 2015. Occurrence, sources and fate of pharmaceuticals and personal care products in the groundwater: a review. Emerging Contaminants, 1 (1), 14-24. otwiera się w nowej karcie
  44. Syed, M., Skonberg, C., and Hansen, S.H., 2016. Mitochondrial toxicity of diclofenac and its metabolites via inhibition of oxidative 1045 1046 1047 1048 1049 1050 1051 1052 1053 1054 1055 1056 1057 1058 1059 1060 1061 1062 1063 1064 1065 1066 1067 1068 1069 1070 1071 1072 1073 1074 1075 1076 1077 1078 1079 1080 1081 1082 1083 1084 1085 1086 1087 1088 1089 1090 1091 1092 1093 1094 1095 1096 1097 1098 1099 1100 1101 1102 1103 otwiera się w nowej karcie
  45. phosphorylation (ATP synthesis) in rat liver mitochondria: Possible role in drug induced liver injury (DILI). Toxicology in Vitro, 31, 93-102. otwiera się w nowej karcie
  46. Szczepa nska, N., Kudłak, B., and Namie snik, J., 2018. Assessing ecotoxicity and the endocrine potential of selected phthalates, BADGE and BFDGE derivatives in relation to environmentally detectable levels. Science of Total Environment, 610-611, 854-866. otwiera się w nowej karcie
  47. Tahrani, L., et al., 2016. Occurrence of antibiotics in pharmaceutical industrial wastewater, wastewater treatment plant and sea waters in Tunisia. Journal of Water and Health, 14 (2), 208-213. otwiera się w nowej karcie
  48. Tian, F., et al., 2016. The antibiotic chloramphenicol may be an effective new agent for inhibiting the growth of multiple myeloma. Oncotarget, 7, 51934. otwiera się w nowej karcie
  49. Torres, N.H., et al., 2015. Detection of hormones in surface and drinking water in Brazil by LC-ESI-MS/MS and ecotoxicological assessment with Daphnia magna. Environmental Monitoring and Assessment, 187, 379. otwiera się w nowej karcie
  50. Touber, M.E., et al., 2007. Multi-detection of corticosteroids in sports dop- ing and veterinary control using high-resolution liquid chromatog- raphy/time-of-flight mass spectrometry. Analytica Chimica Acta, 586 (1-2), 137-146. otwiera się w nowej karcie
  51. van Leeuwen, J.S., et al., 2012. Differential involvement of mitochondrial dysfunction, cytochrome P450 activity, and active transport in the tox- icity of structurally related NSAIDs. Toxicology in Vitro, 26 (2), 197-205. otwiera się w nowej karcie
  52. Warkus, E.L., and Marikawa, Y., 2018. Fluoxetine inhibits canonical Wnt signaling to impair embryoid body morphogenesis: potential terato- genic mechanisms of a commonly used antidepressant. Toxicological Sciences, doi: 10.1093/toxsci/kfy14. otwiera się w nowej karcie
  53. Wieczerzak, M., Kudłak, B., and Namie snik, J., 2015. Environmentally oriented models and methods for the evaluation of drug  drug interaction effects. Critical Review in Analytical Chemistry, 45 (2), 131-155. otwiera się w nowej karcie
  54. Wieczerzak, M., Kudłak, B., and Namie snik, J., 2016. Study of the effect of residues of pharmaceuticals on the environment on the example of bioassay Microtox V R . Monatshefte F€ ur Chemie -Chemical Monthly, 147 (8), 1455-1460. otwiera się w nowej karcie
  55. Wieczerzak, M., Kudłak, B., and Namie snik, J., 2018. Impact of selected drugs and their binary mixtures on the germination of Sorghum bicolor (sorgo) seeds. Environmental Science and Pollution Research, 25 (19), 18717-18727. otwiera się w nowej karcie
  56. Wieczerzak, M., et al., 2016. Modeling of pharmaceuticals mixtures tox- icity with deviation ratio and best-fit functions models. Science of Total Environment, 571, 259-268. otwiera się w nowej karcie
  57. Wieczerzak, M., et al., 2018. Impact of inorganic ions and pH variations on toxicity and endocrine potential of selected environmentally rele- vant pharmaceuticals. Environmental Pollution, 237, 549-558. otwiera się w nowej karcie
  58. Wu, M., et al., 2016. Distribution, fate, and risk assessment of antibiotics in five wastewater treatment plants in Shanghai, China. Environmental Science and Pollution Research, 23 (18), 18055-18063. otwiera się w nowej karcie
  59. Zanuri, N.B.M., Bentley, M.G., and Caldwell, G.S., 2017. Assessing the impact of diclofenac, ibuprofen and sildenafil citrate (Viagra V R ) on the fertilisation biology of broadcast spawning marine invertebrates. Marine Environmental Research, 127, 126-136. 1161 1162 1163 1164 1165 1166 1167 1168 1169 1170 1171 1172 1173 1174 1175 1176 1177 1178 1179 1180 1181 1182 1183 1184 1185 1186 1187 1188 1189 1190 1191 1192 1193 1194 1195 1196 1197 1198 1199 1200 1201 1202 1203 1204 1205 1206 1207 1208 1209 1210 1211 1212 1213 1214 1215 1216 1217 1218 1219
Źródła finansowania:
  • DEC-2013/09/N/NZ8/03247
Weryfikacja:
Politechnika Gdańska

wyświetlono 143 razy

Publikacje, które mogą cię zainteresować

Impact of selected drugs and their binary mixtures on the germination of Sorghum bicolor (sorgo) seeds

2018

Impact of inorganic ions and pH variations on toxicity and endocrine potential of selected environmentally relevant pharmaceuticals

2018

Study of the effect of residues of pharmaceuticals on the environment on the example of bioassay Microtox®

2016

Bisphenols (A, S, and F) affect the basic hormonal activity determined for pharmaceuticals – Study of Saccharomyces cerevisiae

2019
Meta Tagi