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Abstrakt
Short-chain fat-ty acids (SCFAs) are microbial derived metabo-lites, which have multiple beneficial properties. The amount of SCFAs depends on several fac-tors, such as age, diet (mainly intake of dietary fiber), and overall health condition. The normal proportion between SCFAs is 3:1:1 for acetate, proprionate and butyrate, respectively. In col-orectal cancer (CRC) patients, microbiota alter-ations have been shown. Consequently, metab-olome within the gut might change to a large ex-tent. Therefore, the aim of this study was to anal-yse the content of SCFAs and the proportion be-tween SCFAs in the stool obtained from CRC pa-tients in preoperative period. PATIENTS AND METHODS: This study in-cluded 15 patients with CRC in preoperative pe-riod. The stool samples were taken and stored at -80°C in the Fahrenheit Biobank BBMRI.pl, Med-ical University of Gdansk, Poland. The analysis of SCFAs from stool samples was conducted by means of gas chromatography. RESULTS: This study included mainly males (66.67%, n=10). In all patients, there was abnor-mal proportion between SCFAs. The extreme-ly higher concentration of butyrate was noted in 2 samples (13.33%) compared to the rest of pa-tients. However, based on normal proportion be-tween SCFAs, the results <1 for butyrate were noted in 93.33% of patients. CONCLUSIONS: SCFAs pool is altered in CRC patients, among others characterized by low level of butyrate. It should be considered to administer butyrate supplementation to CRC pa-tients especially prior to surgery to support an appropriate preparation to this treatment.
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Autorzy (8)
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Karolina Każmierczak-Siedlecka
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K. Skonieczna-Żydecka
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J. Palma
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Bartosz Kamil Sobocki
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M. Świerblewski
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K. Siedlecka-Kroplewska
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K. Połom
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Pełna treść
- Wersja publikacji
- Accepted albo Published Version
- DOI:
- Cyfrowy identyfikator dokumentu elektronicznego (otwiera się w nowej karcie) 10.26355/eurrev_202302_31384
- Licencja
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Informacje szczegółowe
- Kategoria:
- Publikacja w czasopiśmie
- Typ:
- artykuły w czasopismach
- Opublikowano w:
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European Review for Medical and Pharmacological Sciences
nr 27,
strony 1443 - 1449,
ISSN: 1128-3602 - Język:
- angielski
- Rok wydania:
- 2023
- Opis bibliograficzny:
- Każmierczak-Siedlecka K., Skonieczna-Żydecka K., Palma J., Sobocki B. K., Świerblewski M., Siedlecka-Kroplewska K., Kalinowski L., Połom K.: Microbiota-derived metabolites in colorectal cancer patients in preoperative period// European Review for Medical and Pharmacological Sciences -, (2023),
- DOI:
- Cyfrowy identyfikator dokumentu elektronicznego (otwiera się w nowej karcie) 10.26355/eurrev_202302_31384
- Źródła finansowania:
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- This research was funded in part by the Polish Ministry of Education and Science, grants No. 10/E-389/SPUB/SP/2020 and DIR/WK/2017/01.
- Weryfikacja:
- Politechnika Gdańska
wyświetlono 65 razy
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