Microscopic and Spectroscopic Imaging and Thermal Analysis of Acrylates, Silicones and Active Pharmaceutical Ingredients in Adhesive Transdermal Patches

Marzena Jamrógiewicz; Barbara Mikolaszek; Krystyna Pieńkowska; Małgorzata Sznitowska

doi:https:// doi.org/10.3390/polym14142888

Microscopic and Spectroscopic Imaging and Thermal Analysis of Acrylates, Silicones and Active Pharmaceutical Ingredients in Adhesive Transdermal Patches

Abstrakt

Dermal or transdermal patches are increasingly becoming a noteworthy alternative as
carriers for active pharmaceutical ingredients (APIs), which makes their detailed physicochemical evaluation essential for pharmaceutical development. This paper demonstrates mid-infrared (FTIR) and Raman spectroscopy with complementary microscopic methods (SEM, optical and confocal Raman microscopy) and differential scanning calorimetry (DSC) as tools for the identification of the state of model API (testosterone TST, cytisine CYT or indomethacin IND) in selected adhesive matrices. Among the employed spectroscopic techniques, FTIR and Raman may be used not only
as standard methods for API identification in the matrix, but also as a means of distinguishing commercially available polymeric materials of a similar chemical structures. A novel approach for the preparation of adhesive polymers for the FTIR analysis was introduced. In silicone matrices, all three APIs were suspended, whereas in the case of the acrylic PSA, Raman microscopy confirmed that only IND was dissolved in all three acrylic matrices, and the dissolved fraction of the CYT differed depending on the matrix type. Moreover, the recrystallization of TST was observed in one of the acrylates. Interestingly, a DSC analysis of the acrylic patches did not confirm the presence of the API even if the microscopic images showed suspended particles.

Cytowania

Autorzy (4)

Marzena Jamrógiewicz dr hab. inż. n. farm.
Barbara Mikolaszek mgr
Krystyna Pieńkowska
- Gdański Uniwersytet Medyczny
Małgorzata Sznitowska

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Informacje szczegółowe

Kategoria:: Publikacja w czasopiśmie
Typ:: Publikacja w czasopiśmie
Opublikowano w:: Polymers nr 14, wydanie 14, strony 1 - 26,
ISSN: 2073-4360
Rok wydania:: 2022
DOI:: Cyfrowy identyfikator dokumentu elektronicznego (otwiera się w nowej karcie) https:// doi.org/10.3390/polym14142888
Weryfikacja:: Brak weryfikacji