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Multifunctional cerium-tetracycline coating for titanium implants: A dual approach to antibacterial and corrosion resistance
Abstrakt
Titanium implants, such as Ti6Al4V, are widely used in dentistry and orthopedics due to their excellent biocompatibility and mechanical properties. However, bacterial infections following implantation remain a significant challenge. In this study, we modified the surface of Ti6Al4V with a cerium titanate layer loaded with tetracycline (Tetra), to enhance its bioactivity and antibacterial properties. Scanning Electron Microscopy (SEM), Energy Dispersive Spectroscopy (EDS), and Fourier Transform Infrared microscopy (FT-IR) confirmed the successful modification and uniform drug distribution. The tetracycline adsorbed on the surface was released within 3 h, likely through Ce3+ ion exchange or dissolution of Ce3+ - Tetracycline complex. Potentiodynamic polarization and Electrochemical Impedance Spectroscopy (EIS) indicated increased corrosion resistance. The modified coatings (Ce-Tit-Tetra) exhibited significant antibacterial activity against Staphylococcus aureus, attributed to controlled tetracycline release. Neither this coating nor the cerium only variant (Ce-Tit) showed any activity against Escherichia coli, highlighting challenges in addressing antibiotic resistance. Additionally, the modified material demonstrated greater protein adsorption, indicating improved bioactivity compared to bare Ti6Al4V. These findings suggest that cerium-tetracycline-modified titanium coatings hold promise for enhancing implant performance, but further research is needed to expand their antimicrobial spectrum.
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Autorzy (7)
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Marcel Jakubowski
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Maria Ratajczak
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Anna Ignaszak
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Mariusz Sandomierski
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Informacje szczegółowe
- Kategoria:
- Publikacja w czasopiśmie
- Typ:
- artykuły w czasopismach
- Opublikowano w:
-
MATERIALS CHEMISTRY AND PHYSICS
nr 344,
ISSN: 0254-0584 - Język:
- angielski
- Rok wydania:
- 2025
- Opis bibliograficzny:
- Jakubowski M., Ratajczak M., Banach-Kopeć A., Mania S., Ignaszak A., Voelkel A., Sandomierski M.: Multifunctional cerium-tetracycline coating for titanium implants: A dual approach to antibacterial and corrosion resistance// MATERIALS CHEMISTRY AND PHYSICS -, (2025),
- DOI:
- Cyfrowy identyfikator dokumentu elektronicznego (otwiera się w nowej karcie) 10.1016/j.matchemphys.2025.131111
- Źródła finansowania:
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- National Science Centre, Poland (grant no. 2023/51/D/ST5/00144). Science Centre, Poland (grant no. 2023/51/D/ST5/00144).
- Weryfikacja:
- Politechnika Gdańska
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