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Novel 1,2,4-Oxadiazole Derivatives in Drug Discovery

Abstrakt

Abstract: Five-membered 1,2,4-oxadiazole heterocyclic ring has received considerable attention because of its unique bioisosteric properties and an unusually wide spectrum of biological activities. Thus, it is a perfect framework for the novel drug development. After a century since the 1,2,4-oxadiazole have been discovered, the uncommon potential attracted medicinal chemists’ attention, leading to the discovery of a few presently accessible drugs containing 1,2,4-oxadiazole unit. It is worth noting that the interest in a 1,2,4-oxadiazoles’ biological application has been doubled in the last fifteen years. Herein, after a concise historical introduction, we present a comprehensive overview of the recent achievements in the synthesis of 1,2,4-oxadiazole-based compounds and the major advances in their biological applications in the period of the last five years as well as brief remarks on prospects for further development.

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Wersja publikacji
Accepted albo Published Version
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Creative Commons: CC-BY otwiera się w nowej karcie

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Kategoria:
Publikacja w czasopiśmie
Typ:
artykuły w czasopismach
Opublikowano w:
Pharmaceuticals nr 13,
ISSN: 1424-8247
Język:
angielski
Rok wydania:
2020
Opis bibliograficzny:
Biernacki K., Daśko M., Ciupak O., Kubiński K., Rachoń J., Demkowicz S.: Novel 1,2,4-Oxadiazole Derivatives in Drug Discovery// Pharmaceuticals -Vol. 13,iss. 6 (2020), s.111-
DOI:
Cyfrowy identyfikator dokumentu elektronicznego (otwiera się w nowej karcie) 10.3390/ph13060111
Weryfikacja:
Politechnika Gdańska

wyświetlono 228 razy

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