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Numerical Analysis of Mice Carotid Arteries’ Response Emphasizing the Importance of Material Law Constants’ Validation
Abstrakt
In this paper, a detailed validation of the passive material properties of mice carotid arteries and constants of the Fung and Holzapfel hyperelastic material laws is conducted by means of static nonlinear FEM analyses. The response of the carotid arteries in an inflation test is studied here for the following mouse models: wild-type, mdx, sgcd−/−, Eln+/+, Eln+/−, Fbln5+/+, and Fbln5−/−. All FEM computations are conducted on models that have been preliminarily checked for their reliability. The results of the calculations, namely, the relation between the internal pressure and the artery outer diameter, are verified against experimental responses and the applicability of the laws is assessed. New sets of Holzapfel constitutive relation constants are proposed for Eln+/+ and Fbln5−/− mice. Finally, the problem of carotid artery buckling is also discussed. The buckling pressures of the arteries are predicted using FEM models and nonlinear static analyses. These values are compared with the reference experimental results, which allow for further validation of the constitutive relations. The research emphasizes that computations and numerical methods enable an accurate description of bioengineering processes and behaviors but only if the models used are appropriately validated.
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- Wersja publikacji
- Accepted albo Published Version
- DOI:
- Cyfrowy identyfikator dokumentu elektronicznego (otwiera się w nowej karcie) 10.3390/app14093571
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Informacje szczegółowe
- Kategoria:
- Publikacja w czasopiśmie
- Typ:
- artykuły w czasopismach dostępnych w wersji elektronicznej [także online]
- Opublikowano w:
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Applied Sciences-Basel
ISSN: 2076-3417 - Język:
- angielski
- Rok wydania:
- 2024
- Opis bibliograficzny:
- Sobczyk B., Chróścielewski J., Wilde K., Numerical Analysis of Mice Carotid Arteries’ Response Emphasizing the Importance of Material Law Constants’ Validation, Applied Sciences-Basel, 2024,10.3390/app14093571
- DOI:
- Cyfrowy identyfikator dokumentu elektronicznego (otwiera się w nowej karcie) 10.3390/app14093571
- Źródła finansowania:
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- IDUB
- Weryfikacja:
- Politechnika Gdańska
wyświetlono 7 razy