Pathogenesis of psoriasis in the “omic” era. Part III. Metabolic disorders, metabolomics, nutrigenomics in psoriasis - Publikacja - MOST Wiedzy

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Pathogenesis of psoriasis in the “omic” era. Part III. Metabolic disorders, metabolomics, nutrigenomics in psoriasis

Abstrakt

Psoriasis is a systemic disease that is strictly connected with metabolic disorders (insulin resistance, atherogenic dyslipidemia, arterial hypertension, and cardiovascular diseases). It occurs more often in patients with a more severe course of the disease. Obesity is specially an independent risk factor and it is associated with a worse treatment outcome because of the high inflammatory activity of visceral fatty tissue and the production of inflammatory me - diators involved in the development of both psoriasis and metabolic disorders. However, in psoriasis the activation of the Th17/IL-17 and the abnormalities in the Th17/Treg balance axis are observed, but this pathomechanism does not fully explain the frequent occurrence of metabolic disorders. Therefore, there is a need to look for better biomarkers in the diagnosis, prognosis and monitoring of concomitant disorders and therapeutic effects in psoriasis. In addition, the education on the use of a proper diet as a prophylaxis for the development of the above disorders is an important element of holistic care for a patient with psoriasis. Diet may affect gene expression due to epigenetic modification which encompasses interactions of environment, nutrition and diseases. Patients with psoriasis should be advised to adopt proper diet and dietician support.

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Informacje szczegółowe

Kategoria:
Publikacja w czasopiśmie
Typ:
artykuły w czasopismach
Opublikowano w:
Postępy Dermatologii i Alergologii nr 37, strony 452 - 467,
ISSN: 1642-395X
Język:
angielski
Rok wydania:
2020
Opis bibliograficzny:
Owczarczyk-Saczonek A., Purzycka-Bohdan D., Nedoszytko B., Reich A., Szczerkowska-Dobosz A., Bartosińska J., Batycka-Baran A., Czajkowski R., Dobrucki I., Dobrucki L., Górecka-Sokołowska M., Janaszak-Jasiecka A., Kalinowski L., Krasowska D., Radulska A., Reszka E., Samotij D., Słominski A., Słominski R., Sobalska-Kwapis M., Stawczyk-Macieja M., Strapagiel D., Szczęch J., Żmijewski M., Nowicki R.: Pathogenesis of psoriasis in the “omic” era. Part III. Metabolic disorders, metabolomics, nutrigenomics in psoriasis// Postępy Dermatologii i Alergologii -Vol. 37,iss. 4 (2020), s.452-467
DOI:
Cyfrowy identyfikator dokumentu elektronicznego (otwiera się w nowej karcie) 10.5114/ada.2020.98284
Weryfikacja:
Politechnika Gdańska

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