Pharmacomicrobiomics of cell-cycle specific anti-cancer drugs – is it a new perspective for personalized treatment of cancer patients? - Publikacja - MOST Wiedzy

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Pharmacomicrobiomics of cell-cycle specific anti-cancer drugs – is it a new perspective for personalized treatment of cancer patients?

Abstrakt

Intestinal bacteria are equipped with an enzyme apparatus that is involved in the active biotrans-formation of xenobiotics, including drugs. Pharmacomicrobiomics, a new area of pharmacology, analyses interactions between bacteria and xenobiotics. However, there is another side to the coin. Pharmacotherapeutic agents can significantly modify the microbiota, which consequently affects their efficacy. In this review, we comprehensively gathered scientific evidence on the interplay between anticancer therapies and gut microbes. We also underlined how such interactions might impact the host response to a given therapy. We discuss the possibility of modulating the gut microbiota to increase the effectiveness/decrease the incidence of adverse events during tumor therapy. The anticipation of the future brings new evidence that gut microbiota is a target of interest to increase the efficacy of therapy.

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Informacje szczegółowe

Kategoria:
Publikacja w czasopiśmie
Typ:
artykuły w czasopismach
Opublikowano w:
Gut Microbes nr 15, strony 1 - 20,
ISSN: 1949-0976
Język:
angielski
Rok wydania:
2023
Opis bibliograficzny:
Kaźmierczak-Siedlecka K., Bulman N., Ulasiński P., Sobocki B. K., Polom K., Marano L., Kalinowski L., Skonieczna-Żydecka K.: Pharmacomicrobiomics of cell-cycle specific anti-cancer drugs – is it a new perspective for personalized treatment of cancer patients?// Gut Microbes -Vol. 15,iss. 2 (2023), s.1-20
DOI:
Cyfrowy identyfikator dokumentu elektronicznego (otwiera się w nowej karcie) 10.1080/19490976.2023.2281017
Źródła finansowania:
  • This research was funded by the Polish Ministry of Education and Science, grant no. 10/E-389/SPUB/SP/2020
Weryfikacja:
Politechnika Gdańska

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