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Abstrakt
UV and visible radiation may influence on the stability of some active pharmaceutical ingredients and in a consequence destabilizes such medicinal products, causes changes
in its physicochemical properties also with negative pharmacological and sometimes even toxic effects. For this reason it is important to conduct the routine testing photostability. The knowledge of chemistry and technology as well as some methods of medicinal substances protection are extremely important to maintain the therapeutic effect
and the appropriate formulation principles. Guidelines for photostability testing were described focused on either substances alone or finished medicinal products. In this paper, various photostabilizers or quenchers which are added to tablets or liquid forms of drugs as excipients are discussed. Currently, there are used some physical methods, nanotechnology and supramolecular technology to minimize the impact of UV and visible radiation on the stability and the final quality of the pharmaceutical products.
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Informacje szczegółowe
- Kategoria:
- Publikacja w czasopiśmie
- Typ:
- Publikacja w czasopiśmie
- Opublikowano w:
-
Farmacja Polska
nr 68,
wydanie 12,
strony 858 - 866,
ISSN: 0014-8261 - Rok wydania:
- 2012
- Weryfikacja:
- Brak weryfikacji
wyświetlono 95 razy