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Synthesis, crystal structure and cytotoxic activity of ruthenium(II) piano-stool complex with N,N-chelating ligand
Abstrakt
A mononuclear compound of the general formula [(η6-p-cymene)RuIICl(2,2′-PyBIm)]PF6 has been synthesized from a bidentate N,N-donor ligand, viz. 2,-(2′-pyridyl)benzimidazole (2,2′-PyBIm) and the corresponding chloro-complex [(η6-p-cymene)Ru(μ-Cl)Cl]2 (precursor). The isolated coordination compound was characterized by IR, UV–vis and 1H, 13C NMR spectroscopies. The single crystal X-ray analysis of the complex reveals that the asymmetric part of the unit cell consists of two symmetrically independent, [(η6-p-cymene)RuCl(2,2′-PyBIm)]+ cationic complexes. Each cation exhibits a pseudo-octahedral three-legged piano-stool geometry, in which three “legs” are occupied by one chloride ion and two nitrogen donor atoms of the chelating ligand 2,2′-PyBIm. The Hirshfeld surface analysis of obtained complex was determined, too. The ionic nature of the compound is identified by a strong band at around 830 cm−1 due to the νP−F stretching mode of the PF6− counter ion. The electronic spectrum of this monomeric complex displays high intensity bands in the ultraviolet region assignable to π→π*/n→π* transitions, as well as a band attributable to the metal-to-ligand charge transfer (MLCT) dπ(Ru)→π*(L) transition. Additionally, the complex has been screened for its cytotoxicity against three human cancer lines: non-small cell lung carcinoma (A549), colon adenocarcinoma (HT29) and breast adenocarcinoma (MCF-7) as well as normal mice fibroblast cells (BALB/3T3). The complex demonstrated a moderate antiproliferative activity against the cell lines tested.
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Autorzy (7)
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Patrycja Rogala mgr
- Jan Kochanowski University, Kielce Institute of Chemistry
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Agnieszka Jabłońska-Wawrzycka dr
- Jan Kochanowski University, Kielce Institute of Chemistry
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Agnieszka Borek
- Jan Kochanowski University, Kielce Institute of Chemistry
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Agnieszka Błażejczyk
- Polish Academy of Sciences, Wroclaw Institute of Immunology and Experimental Therapy
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Joanna Wietrzyk
- Polish Academy of Sciences, Wroclaw Institute of Immunology and Experimental Therapy
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Barbara Barszcz dr hab.
- Jan Kochanowski University, Kielce Institute of Chemistry
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Informacje szczegółowe
- Kategoria:
- Publikacja w czasopiśmie
- Typ:
- artykuł w czasopiśmie wyróżnionym w JCR
- Opublikowano w:
-
JOURNAL OF MOLECULAR STRUCTURE
nr 1126,
strony 74 - 82,
ISSN: 0022-2860 - Język:
- angielski
- Rok wydania:
- 2016
- Opis bibliograficzny:
- Rogala P., Jabłońska-Wawrzycka A., Kazimierczuk K., Borek A., Błażejczyk A., Wietrzyk J., Barszcz B.: Synthesis, crystal structure and cytotoxic activity of ruthenium(II) piano-stool complex with N,N-chelating ligand// JOURNAL OF MOLECULAR STRUCTURE. -Vol. 1126, (2016), s.74-82
- DOI:
- Cyfrowy identyfikator dokumentu elektronicznego (otwiera się w nowej karcie) 10.1016/j.molstruc.2016.01.079
- Weryfikacja:
- Politechnika Gdańska
wyświetlono 139 razy
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