The Interplay between Endogenous and Foodborne Pro-Oxidants and Antioxidants in Shaping Redox Homeostasis

Patrycja Jakubek; Karol Parchem; Mariusz R. Wieckowski; Agnieszka Bartoszek-Pączkowska

doi:10.3390/ijms25147827

The Interplay between Endogenous and Foodborne Pro-Oxidants and Antioxidants in Shaping Redox Homeostasis

Abstrakt

Oxidative stress has been known about in biological sciences for several decades; however, the understanding of this concept has evolved greatly since its foundation. Over the past years, reactive oxygen species, once viewed as solely deleterious, have become recognized as intrinsic components of life. In contrast, antioxidants, initially believed to be cure-all remedies, have failed to prove their efficacy in clinical trials. Fortunately, research on the health-promoting properties of antioxidants has been ongoing. Subsequent years showed that the former assumption that all antioxidants acted similarly was greatly oversimplified. Redox-active compounds differ in their chemical structures, electrochemical properties, mechanisms of action, and bioavailability; therefore, their efficacy in protecting against oxidative stress also varies. In this review, we discuss the changing perception of oxidative stress and its sources, emphasizing everyday-life exposures, particularly those of dietary origin. Finally, we posit that a better understanding of the physicochemical properties and biological outcomes of antioxidants is crucial to fully utilize their beneficial impact on health.

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Autorzy (4)

Patrycja Jakubek
Karol Parchem dr inż.
Mariusz R. Wieckowski
Agnieszka Bartoszek-Pączkowska prof. dr hab. inż.

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Publikacja w czasopiśmie

Typ:

artykuły w czasopismach

Opublikowano w:

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES nr 25, strony 7827 - .,
ISSN: 1661-6596

Język:

angielski

Rok wydania:

2024

Opis bibliograficzny:

Jakubek P., Parchem K., Wieckowski M. R., Bartoszek-Pączkowska A.: The Interplay between Endogenous and Foodborne Pro-Oxidants and Antioxidants in Shaping Redox Homeostasis// INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES -,iss. 25 (2024), s.7827-.

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