Triazoloacridone C-1305 impairs XBP1 splicing by acting as a potential IRE1α endoribonuclease inhibitor - Publikacja - MOST Wiedzy

Twoje konto

zaloguj

Wyszukiwarka

Triazoloacridone C-1305 impairs XBP1 splicing by acting as a potential IRE1α endoribonuclease inhibitor

Abstrakt

Inositol requiring enzyme 1 alpha (IRE1α) is one of three signaling sensors in the unfolding protein response (UPR) that alleviates endoplasmic reticulum (ER) stress in cells and functions to promote cell survival. During conditions of irrevocable stress, proapoptotic gene expression is induced to promote cell death. One of the three signaling stressors, IRE1α is an serine/threonine-protein kinase/endoribonuclease (RNase) that promotes nonconventional splicing of XBP1 mRNA that is translated to spliced XBP1 (XBP1s), an active prosurvival transcription factor. Interestingly, elevated IRE1α and XBP1s are both associated with poor cancer survival and drug resistance. In this study, we used next-generation sequencing analyses to demonstrate that triazoloacridone C-1305, a microtubule stabilizing agent that also has topoisomerase II inhibitory activity, dramatically decreases XBP1s mRNA levels and protein production during ER stress conditions, suggesting that C-1305 does this by decreasing IRE1α’s endonuclease activity.

Cytowania

  • 1 0

    CrossRef

  • 0

    Web of Science

  • 9

    Scopus

Autorzy (7)

Cytuj jako

Pełna treść

pobierz publikację
pobrano 80 razy
Wersja publikacji
Accepted albo Published Version
Licencja
Creative Commons: CC-BY otwiera się w nowej karcie

Słowa kluczowe

Informacje szczegółowe

Kategoria:
Publikacja w czasopiśmie
Typ:
artykuły w czasopismach
Opublikowano w:
CELLULAR & MOLECULAR BIOLOGY LETTERS nr 26, strony 1 - 17,
ISSN: 1425-8153
Język:
angielski
Rok wydania:
2021
Opis bibliograficzny:
Bartoszewska S., Króliczewski J., Crossman D., Pogorzelska A., Bagiński M., Collawn J. F., Bartoszewski R.: Triazoloacridone C-1305 impairs XBP1 splicing by acting as a potential IRE1α endoribonuclease inhibitor// CELLULAR & MOLECULAR BIOLOGY LETTERS -Vol. 26,iss. 1 (2021), s.1-17
DOI:
Cyfrowy identyfikator dokumentu elektronicznego (otwiera się w nowej karcie) 10.1186/s11658-021-00255-y
Źródła finansowania:
Weryfikacja:
Politechnika Gdańska

wyświetlono 124 razy

Publikacje, które mogą cię zainteresować

The Unfolded Protein Response: A Double-Edged Sword for Brain Health

2023

c-Myc inhibition and p21 modulation contribute to unsymmetrical bisacridines-induced apoptosis and senescence in pancreatic cancer cells

2024

Metabolic transformation of antitumor acridinone C-1305 but not C-1311 via selective cellular expression of UGT1A10 increases cytotoxic response: implications for clinical use.

  • M. Pawłowska,
  • R. Chu,
  • B. Fedejko-Kap
  • + 4 autorów
2013

Design, synthesis, and biological evaluation of tetrahydroquinolinones and tetrahydroquinolines with anticancer activity

2022
Meta Tagi